蜂巢状乳液静电纺纳米纤维的制备及其缓释性能研究  

Preparation of emulsion electrospun nanofibers with bionic honeycomb structure and their release properties

作　　者：乜炆佳 章依洋 叶子易 李庭晓 Mie Wenjia;Zhang Yiyang;Ye Ziyi;Li Tingxiao(School of Textile and Fashion,Shanghai University of Engineering Science,Shanghai 201620)

机构地区：[1]上海工程技术大学纺织服装学院,上海201620

出　　处：《化工新型材料》2024年第S02期228-232,共5页New Chemical Materials

基　　金：上海高校创新团队建设项目(cx2309014)。

摘　　要：静电纺纳米纤维具备可控的结构、高表面积和与细胞外基质(ECM)相似的结构,是伤口愈合中具有较大潜力的材料。利用乳液静电纺丝方法制备了聚乳酸(PLA)和胶原蛋白(Col)芯壳结构纳米纤维,在内层负载模型药物盐酸四环素(TCH),并通过改变接收装置的网孔形状,制备出仿自然界蜂巢结构的纳米纤维膜,探究蜂巢状纳米纤维膜形貌结构与其相关理化性能的影响规律。结果表明:PLA和Col的浓度为15%,且比例为1∶1时可纺性较好,通过采用失水山梨醇油酸酯(Span 80)包盐酸四环素(TCH)静电纺乳液蜂巢状纳米纤维。本项目制备的PLA/Col仿生蜂巢状乳液静电纺纳米纤维膜具备长效缓释功能,在愈伤修复、皮肤敷料等生物医学领域中有着广阔的应用前景。Electrospun nanofibers have a controllable structure,high surface area and a structure similar to extracellular matrix(ECM),making them great potential materials for wound healing.In this project,polylactic acid(PLA)and collagen(Col)core-shell structured nanofibers were prepared by emulsion electrospinning,and the model drug tetracycline hydrochloride(TCH)was loaded on the inner layer.Nanofiber membranes imitating the natural honeycomb structure were prepared by changing the mesh shape of the receiving device,and the influence of the morphological structure of the honeycomb nanofiber membranes on their related physical and chemical properties was explored.The results showed that when the concentration of PLA and Col was 15%and the ratio was 1∶1,the spinnability was better.Honeycomb emulsion electrospun nanofibers were made by using sorbitan oleate(Span 80)encapsulated tetracycline hydrochloride(TCH).The results indicated that the PLA/Col bionic honeycomb emulsion electrospun nanofiber membranes prepared in this project had a long-term sustained release function,demonstrating a broad application prospect in biomedical fields such as wound healing and skin dressing.

关 键 词：聚乳酸 胶原蛋白 药物缓释 乳液静电纺 蜂巢结构 

分 类 号：TQ340.64[化学工程—化纤工业]