关于宫颈病变患者HPV感染情况及阴道菌群变化的相关分析  

Analysis of HPV infection and changes in vaginal flora in patients with cervical lesions

作　　者：许英慧 邓燕杰 XU Yinghui;DENG Yanjie(Dalian Women and Children's Medical Centre(Group),Dalian,Liaoning 116083,China)

机构地区：[1]大连市妇女儿童医疗中心(集团),辽宁116083

出　　处：《中国微生态学杂志》2024年第10期1231-1236,共6页Chinese Journal of Microecology

摘　　要：高级别鳞状上皮内病变(high-grade squamous intraepithelial lesion,HSIL)是一种宫颈癌前病变,若不及时治疗,有发展为浸润性鳞状细胞癌的风险。众所周知,持续感染人乳头瘤病毒(human papillomavirus,HPV),特别是高危人乳头瘤病毒(high risk human papillomavirus,HR-HPV),是宫颈癌前病变和宫颈癌发生的前提条件。由于从HR-HPV感染发展到宫颈癌需要很长的时间,且患者在早期几乎无任何不适症状,因此我们要及时发现与宫颈病变相关的因素,来降低宫颈癌的发生率。研究发现,宫颈病变的患者在早期就会出现阴道菌群失调。本文查阅大量资料,探讨宫颈病变、HPV感染与阴道菌群之间的关系,旨在为宫颈病变的预防和治疗提供新的思路。High-grade squamous intraepithelial lesion(HSIL) is a precancerous lesion of the cervix which,if left untreated,is at risk of developing into invasive squamous cell carcinoma.It is well known that persistent infection with human papillomavirus(HPV),especially high risk human papillomavirus(HR-HPV),is a prerequisite for the development of cervical precancer and cervical cancer.Since it takes a long time for HR-HPV infection to progress to cervical cancer,and the patients have few or no symptoms in the early stages,it is important to identify the factors associated with cervical lesions in order to reduce the incidence of cervical cancer.It has been found that patients with cervical lesions have a dysbiosis of the vaginal flora in the early stages.In this paper,we reviewed a large amount of data and discussed the relationship of cervical lesions and HPV infection with vaginal flora,with the aim of providing new ideas for the prevention and treatment of cervical lesions.

关 键 词：高级别鳞状上皮内瘤变 阴道菌群 人乳头瘤病毒 

分 类 号：R711.74[医药卫生—妇产科学]