PCDH10 is a neuronal receptor for western equine encephalitis virus  

作　　者：Yan Yang Li-Xin Zhao Zhen-Qi Li Su-Yun Wang Zhi-Sheng Xu Yan-Yi Wang 

机构地区：[1]Key Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei,China [2]University of Chinese Academy of Sciences,Beijing,China [3]State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei,China

出　　处：《Cell Research》2024年第11期802-805,共4页细胞研究（英文版）

基　　金：supported by the National Key R&D Program of China(2023YFC2306100,2023YFC2305900);the National Natural Science Foundation of China(32170930,U23A20168);the Major Scientific and Technological Project of Hubei Province(2022ACA005);the Major Project of Guangzhou National Laboratory(GZNL2024A01014).

摘　　要：Dear Editor,Western equine encephalitis virus(WEEV)is a mosquito-borne alphavirus that uses birds as reservoirs and causes severe encephalitis and death in humans and equids.1 Currently no approved vaccines and antivirals are available and it is urgently needed to investigate the mechanisms of WEEV–host interaction for preparedness for the potential re-emerging of WEEV.The viral spike of WEEV consisting of three heterodimers of E2-E1 glycoproteins has been demonstrated to mediate cellular entry of WEEV.2 WEEV infection causes encephalitis,but a neuronal receptor for WEEV remains enigmatic.

关 键 词：ENCEPHALITIS DEATH RESERVOIRS 

分 类 号：R373[医药卫生—病原生物学]