AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension  

作　　者：Mengqi Li Yu Wang Xiaoyan Wei Wei-Feng Cai Yan-Hui Liu Jianfeng Wu Yan Chen Jinye Xiong Li-Feng Cui Mingxia Zhu Cixiong Zhang Liyun Lin Yong Yu Hai-Long Piao Sheng-Cai Lin Chen-Song Zhang 

机构地区：[1]State Key Laboratory for Cellular Stress Biology,School of Life Sciences,Xiamen University,Xiamen,Fujian,China.2 Xiamen Key Laboratory of Radiation Oncology,Xiamen Cancer Center,The First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen,Fujian,China.3 Laboratory Animal Research Centre,Xiamen University,Xiamen,Fujian,China.4 CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,Liaoning,China.5 The Zhongzhou Laboratory for Integrative Biology,Henan University,Zhengzhou,Henan,China

出　　处：《Cell Research》2024年第11期806-809,共4页细胞研究（英文版）

基　　金：supported by grants from the National Key R&D Program of China(2022YFA0806501);the National Natural Science Foundation of China(92057204,82088102,32070753,31900542,91854208,31922034 and 323B2035);the Fundamental Research Funds for the Central Universities(20720200069);the Project“111”sponsored by the State Bureau of Foreign Experts and Ministry of Education of China(BP2018017);the Joint Funds for the Innovation of Science and Technology,Fujian province(2021Y9232,2021Y9227 and 2023Y9448);the Fujian provincial health technology project(2022ZD01005 and 2022ZQNZD009);the Special Research Funds for Local Science and Technology Development Guided by Central Government(2023L3020);the XMU-Fujian Cancer Hospital cooperation grant for the Research Center of Metabolism and Tumor,the XMU Training Program of Innovation and Entrepreneurship for Undergraduates(2021×1183 and 2022Y1233);the Agilent Applications and Core Technology-University Research Grant(4769).

摘　　要：Dear Editor,Calorie restriction(CR)that chronically reduces average daily caloric intake without causing malnutrition has been recognized as a non-pharmacological dietary behavior for improving health.1 The benefits of CR have been observed in various species,including yeast,nematodes,mice,and primates,showing a general link between reduced food intake and longevity.2 During CR,organisms undergo metabolic changes or adaptations,such as a shift from primarily consuming glucose to fatty acid and amino acid catabolism.3,4 However.

关 键 词：consuming MEDIA showing 

分 类 号：O62[理学—有机化学]