Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI  

作　　者：Qing-Qiang Gao Jian-Huai Chen Jia-Ming Lu Bin Wang You-Feng Han Song-Zhan Gao Jie Yang Yu-Tian Dai 

机构地区：[1]Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China [2]Department of Andrology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China [3]Department of Andrology,Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China [4]Department of Radiology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China [5]Department of Andrology,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [6]Department of Urology,Jiangsu Provincial People’s Hospital,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China [7]Department of Urology,People’s Hospital of Xinjiang Kizilsu Kirgiz Autonomous Prefecture,Kizilsu Kirgiz Autonomous Prefecture 845350,China

出　　处：《Asian Journal of Andrology》2024年第5期510-516,共7页亚洲男性学杂志（英文版）

基　　金：supported by grants from the Nanjing Medical Technology Development Project(No.YKK19059);Excellent Young Doctor Training Program of Jiangsu Province Hospital of Chinese Medicine(No.2023QB0126);Jiangsu Province Graduate Research and Practice Innovation Program Project-School Assisted General Project(No.SJCX23_0804);the General project of Natural Science Foundat。

摘　　要：Ejaculation is regulated by the central nervous system.However,the central pathophysiology of primary intravaginal anejaculation(PIAJ)is unclear.The present study aimed to examine the changes in regional brain activity and functional connectivity underlying PIAJ.A total of 20 PIAJ patients and 16 healthy controls(HCs)were enrolled from September 2020 to September 2022 in the Department of Andrology,Nanjing Drum Tower Hospital(Nanjing,China).Magnetic resonance imaging data were acquired from all participants and then were preprocessed.The measures of fractional amplitude of low-frequency fluctuation(fALFF),regional homogeneity(ReHo),and functional connectivity(FC)were calculated and compared between the groups.PIAJ patients showed increased fALFF values in the left precuneus compared with HCs.Additionally,PIAJ patients showed increased ReHo values in the left precuneus,left postcentral gyrus,left superior occipital gyrus,left calcarine fissure,right precuneus,and right middle temporal gyrus,and decreased ReHo values in the left inferior parietal gyrus,compared with HCs.Finally,brain regions with altered fALFF and ReHo values in PIAJ patients showed increased FC with widespread cortical regions,which included the frontal,parietal,temporal,and occipital regions,compared with HCs.In conclusion,increased regional brain activity in the parietal,temporal,and occipital regions,and increased FC between these brain regions,may be associated with PIAJ occurrence.

关 键 词：fractional amplitude of low-frequency fluctuation functional connectivity primary intravaginal anejaculation regional homogeneity resting-state functional magnetic resonance imaging 

分 类 号：R697[医药卫生—泌尿科学]