Association between anti-Müllerian hormone concentrations and sperm retrieval outcomes in patients with idiopathic nonobstructive azoospermia:a systematic review and meta-analysis  

作　　者：Hong Xiao Yi-Lang Ding Peng Yang Qiang Chen Hai-Lin Huang Xi Chen Hui-Liang Zhou Song-Xi Tang 

机构地区：[1]Department of Andrology and Sexual Medicine,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China

出　　处：《Asian Journal of Andrology》2024年第5期522-527,共6页亚洲男性学杂志（英文版）

摘　　要：Microdissection testicular sperm extraction(mTESE)is commonly performed to retrieve sperm in the testes for assisted reproductive techniques in patients with idiopathic nonobstructive azoospermia(iNOA).However,the success rate of sperm retrieval varies among individuals.We aim to investigate the association between clinical parameters and sperm retrieval outcomes in patients with iNOA.We searched PubMed,EMBASE,and Web of Science from database inception to August 2,2023.The main measure was whether sperm retrieval was successful in patients with iNOA who underwent mTESE.Pooled estimates of the sperm retrieval rate and weighted mean differences were calculated using random-effects models.The overall sperm retrieval rate was 36.8%(95%confidence interval[CI]:27.5%-46.0%,I 2=95.0%)in nine studies comprising 1892 patients with iNOA.No significant differences were found in age,testicular volume,serum total testosterone concentrations,or inhibin B concentrations between positive and negative sperm retrieval outcomes.Lower anti-Müllerian hormone concentrations in patients with iNOA were associated with a positive outcome of mTESE(weighted mean differences:−2.70;95%CI:−3.94-−1.46,I 2=79.0%).In conclusion,this study shows a significant relationship between anti-Müllerian hormone and sperm retrieval outcomes in patients with iNOA,while age,testicular volume,total testosterone,and inhibin B show no significant association.These findings have important implications for assessing the potential success of sperm retrieval and selecting appropriate treatment strategies in patients with iNOA.

关 键 词：anti-Müllerian hormone idiopathic nonobstructive azoospermia male infertility META-ANALYSIS sperm retrieval 

分 类 号：R698.2[医药卫生—泌尿科学]