Moxibustion versus non-moxibustion for immune reconstitution inflammatory syndrome in patients with HIV:A 48-week prospective cohort study  

艾灸V.S.非艾灸治疗HIV感染者免疫重建炎性综合征:一项48周的前瞻性队列研究

作　　者：Guo-jian GAO Hui-jun GUO Xin LI Yao-kai CHEN Xing-hua TAN Yu-qi YANG Jian-ping MA Shui-qing LIU Quan-sheng FENG Wen ZOU Ji-peng DONG Jian WANG Ying LIU 高国建;郭会军;李鑫;陈耀凯;谭行华;杨玉琪;马建萍;刘水青;冯全生;邹雯;董继鹏;王健;刘颖(中国中医科学院研究生院,北京100700;河南中医药大学第一附属医院,郑州450008;首都医科大学附属北京地坛医院感染中心,北京100015;重庆市公共卫生医疗救治中心,重庆400030;广州市第八人民医院,广州510060;云南省中医中药研究院,昆明650223;新疆维吾尔自治区中医院,乌鲁木齐830000;贵阳市公共卫生救治中心,贵阳550001;成都中医药大学,成都610075;中国中医科学院中医药防治艾滋病研究中心,北京100700)

机构地区：[1]Graduate School of China Academyof Chinese Medical Sciences,Beijing100700,China [2]The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China [3]Infection Center of Beijing Ditan Hospital Affiliated to Capital Medical University,Beijing 100015,China [4]Chongqing Public Health Medical Center,Chongqing 400030,China [5]Guangzhou Eighth People'sHospital,Guangzhou 510060,China [6]Yunnan Institute of Traditional Chinese Medicine,Kunming 650223,China [7]Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,China [8]Guiyang Public Health Treatment Center,Guiyang 550001,China [9]Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China [10]Research Center of AIDS Treatment with Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《World Journal of Acupuncture-Moxibustion》2024年第4期318-324,共7页世界针灸杂志（英文版）

基　　金：Supported by National Major Science and Technology Projects:2017zX10205501;National Public Welfare Industry Scientific Research Special:201507005;2023 Beijing TCM Science and Technology Development Fund Project-Youth Project:BjzYQN-2023-05;China Academy of Chinese Medical Sciences Outstanding Youth Program:ZZ15-YQ-048.

摘　　要：Objective:To assess the effects of moxibustion on immune reconstitution inflammatory syndrome(IRIS)in patients with acquired immune deficiency syndrome(AIDS)by tracking T-cell subsets over a 48-week prospective cohort study.Methods:Patients with AIDS who had low viral loads and weakened immune systems were divided into a moxibustion group and a non-moxibustion group.The non-moxibustion group received standard western treatment,including 48 weeks of antiretroviral therapy(ART).The moxibustion group received ART combined with moxibusion therapy,administered three times weekly.Each treatment lasted 10 weeks,with four courses completed over 48 weeks,separated by 2-week breaks.At different time points,plasma levels of CD4^(+),CD8^(+),CD45RAt,CD45RO^(+),CD4^(+)CD28^(+),CD8^(+)CD38^(+),and CD4^(+)CD38^(+)were compared between the two groups.Results:A total of 200 eligible patients were included and divided into two groups,with 100 in the non-moxibustion group and 100 in the moxibustion group.At Week 24,the CD4^(+)T cell count was(180.71±79.62)cells/μL in the non-moxibustion group and(218.22±82.02)cells/μL in the moxibustion group.By Week 36,the counts were(204.83±96.78)cells/μuL and(239.35±81.90)cells/μL,respectively.At Weeks 24 and 48,the CD8^(+)T cell and CD45RO^(+)counts were higher in the moxibustion group than in the non-moxibustion group(P<0.05).By Week 48,the CD45RA^(+)count was also higher in the moxibustion group(P<0.05).At Week 24,the CD4^(+)CD25^(+)count was lower in the moxibustion group than in the non-moxibustion group(P<0.05).

关 键 词：Acquired immune deficiency syndrome MOXIBUSTION Antiretroviral therapy T cell subset 

分 类 号：R246.1[医药卫生—针灸推拿学]