基于神经元细胞周期重启探讨针灸防治阿尔茨海默病的机制  

Research progress of mechanism of acupuncture and moxibustion on prevention and treatment of Alzheimer’s disease based on the neuronal cell cycle re-entry

作　　者：罗泳茵 单晓倩 宋京京 郝楠 赵岚[1,2] LUO Yong-yin;SHAN Xiao-qian;SONG Jing-jing;HAO Nan;ZHAO Lan(The First Affiliated Hospital of Tianjin University of Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Acupuncture and Moxibustion,Tianjin 300381)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《针刺研究》2024年第11期1205-1212,共8页Acupuncture Research

基　　金：国家自然科学基金项目(No.82074533)。

摘　　要：阿尔茨海默病(AD)是最常见的痴呆类型。研究表明,神经元细胞周期重启是AD早期的异常改变,也是介导神经元死亡的关键原因之一,而针灸治疗AD的作用机制可能与调控神经元异常细胞周期有关。本文对AD神经元细胞周期重启的发生及其介导的细胞死亡机制进行综述,列举了影响神经元细胞周期重启的因素,探讨针灸通过调节AD细胞周期蛋白、AD神经元细胞周期重启影响因素(β-淀粉样蛋白及Tau蛋白磷酸化水平、氧化应激、脑源性神经营养因子)多靶点调控神经元细胞周期重启防治AD的可能机制,以期为针灸防治AD的应用与研究提供参考。Alzheimer’s disease(AD)is the most common type of dementia.Studies have shown that neuronal cell cycle re-entry is an abnormal change in the early stage of AD,and it is also one of the key reasons for mediating neuronal death.The mechanism of acupuncture and moxibustion in treating AD may be related to the regulation of abnormal cell cycle.In this article,we reviewed the occurrence of AD neuronal cell cycle re-entry and its mediated cell death mechanism,listed the factors affecting neuronal cell cycle re-entry,explored the possible mechanism of acupuncture and moxibustion in preventing and treating AD by regulating AD cell cycle protein,AD neuronal cell cycle re-entry influencing factors(β-amyloid protein and Tau protein phosphorylation level,oxidative stress,brain-derived neurotrophic factor),the multi-target regulation of neuronal cell cycle re-entry,so as to provide reference for the application and research of acupuncture and moxibustion in preventing and treating AD.

关 键 词：阿尔茨海默病 针刺 艾灸 神经元 细胞周期 

分 类 号：R246.6[医药卫生—针灸推拿学]