针刺改善慢性阻塞性肺疾病作用机制的研究进展  

Progress of experimental research on the underlying mechanisms of acupuncture in improving chronic obstructive pulmonary disease

作　　者：姜林鸿 李培君 王颖祺 包弋蝶 邓信辽 吴卫兵 刘晓丹 JIANG Lin-hong;LI Pei-jun;WANG Ying-qi;BAO Yi-die;DENG XIN-liao;WU Wei-bing;LIU Xiao-dan(School of Rehabilitation Science,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai University of Sport,Shanghai 200438;Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation,Ministry of Education,Shanghai 201203;Institute of Rehabilitation Medicine,Shanghai Academy of Traditional Chinese Medicine,Shanghai 201203)

机构地区：[1]上海中医药大学康复医学院,上海201203 [2]上海体育大学,上海200438 [3]中医智能康复教育部工程研究中心,上海201203 [4]上海市中医药研究院康复医学研究所,上海201203

出　　处：《针刺研究》2024年第11期1213-1219,共7页Acupuncture Research

基　　金：国家自然科学基金面上项目(No.82072551);上海市卫生健康委员会卫生健康学科带头人项目(No.2022XD044);上海市“超级博士后”资助项目(No.2022510)。

摘　　要：针刺治疗慢性阻塞性肺疾病(COPD)临床疗效确切,本文检索和整理近年来针刺治疗COPD基础实验研究方面的国内外文献并进行梳理和总结,结果显示针刺改善COPD的作用机制主要包括抑制炎性反应、抑制氧化应激和调节蛋白酶/抗蛋白酶失衡等方面,为临床应用针刺治疗COPD提供理论依据和新思路。Chronic obstructive pulmonary disease(COPD)is a common disease that seriously jeopardizes human health and affects patients’quality of life.The clinical efficacy of acupuncture in treating COPD is definite,and it can exert positive effects such as improving skeletal muscle degradation,airway mucus hypersecretion and pulmonary vascular remodeling in COPD rats.In recent years,the research on the underlying mechanisms of acupuncture in improving COPD has become more and more in-depth.In this review,we searched and organized the domestic and international literatures on the basic experimental aspects of acupuncture in COPD treatment,and found that the underlying mechanisms of acupuncture mainly include(1)reducing the number of inflammatory cells in the lung tissue,regulating inflammasome,epigenetic modification and inflammation-related signaling pathways to inhibit the synthesis and release of cytokines,inhibiting the level of autophagy and inhibiting the release and expression of neurotransmitters;(2)improving antioxidant capacity and reducing oxidative damage,suppressing oxidative stress in the lung tissue;(3)regulating protease/antiprotease imbalance to maintain pulmonary homeostasis.These results provide a theoretical basis and a new way of thinking for the clinical application of acupuncture in the treatment of COPD.

关 键 词：慢性阻塞性肺疾病 针刺 作用机制 综述 

分 类 号：R246.1[医药卫生—针灸推拿学]