有创-无创呼吸机序贯机械通气联合肺表面活性剂治疗新生儿呼吸窘迫综合征的临床效果  

Clinical effect of invasive-noninvasive ventilator sequential mechanical ventilation combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome

作　　者：陆琴 吴薇 钱睿源 芦亚娟 LU Qin;WU Wei;QIAN Ruiyuan;LU Yajuan(Department of Neonatology,Changzhou Children’s Hospital Affiliated to Nantong University,Jiangsu Province,Changzhou 213000,China)

机构地区：[1]南通大学附属常州儿童医院新生儿科,江苏常州213000

出　　处：《妇儿健康导刊》2024年第21期56-60,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：常州市科学技术局应用基础研究项目(CJ20220227)。

摘　　要：目的探讨有创-无创呼吸机序贯机械通气联合肺表面活性剂治疗新生儿呼吸窘迫综合征(RDS)的临床效果。方法选取2022年6月至2023年12月南通大学附属常州儿童医院新生儿科收治的86例RDS早产儿,采用随机数字表法分为两组。对照组(43例)给予有创机械通气联合肺表面活性剂,观察组(43例)给予有创-无创呼吸机序贯机械通气联合肺表面活性剂,比较两组不同时间点的血气指标、治疗情况、并发症总发生率。结果观察组治疗24、48、72h的动脉血氧分压高于对照组,动脉血二氧化碳分压低于对照组(P<0.05);观察组氧疗时间、机械通气时间和住院时间均短于对照组,差异有统计学意义(P<0.05);观察组并发症总发生率(4.65%)低于对照组(18.60%),差异有统计学意义(P<0.05)。结论有创-无创呼吸机序贯机械通气联合肺表面活性剂可以改善RDS早产儿的血气指标,促进康复,减少并发症。[Abstract]Objective To investigate the clinical effect of invasive-noninvasive ventilator sequential mechanical ventilation combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome(RDS).Methods From June 2022 to December 2023,86 premature infants with RDS in the Department of Neonatology,Changzhou Children’s Hospital Affiliated to Nantong University were selected and divided into two groups by the random number table method.The control group(43 cases)was given invasive mechanical ventilation combined with pulmonary surfactant,and the observation group(43 cases)was given invasive-noninvasive ventilator sequential mechanical ventilation combined with pulmonary surfactant.The blood gas indexes at different time points,treatment status,and total complication rate between the two groups were compared.Results After 24,48,and 72 hours treatment,the arterial partial pressure of oxygen in the observation group was higher than that in the control group,and the arterial partial pressure of carbon dioxide was lower than that in the control group(P<0.05).The oxygen therapy time,mechanical ventilation time and hospitalization time in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of complications in the observation group(4.65%)was lower than that in the control group(18.60%),the difference was statistically significant(P<0.05).Conclusion Invasive-noninvasive ventilator sequential mechanical ventilation combined with pulmonary surfactant can improve blood gas index of premature infants with RDS,promote recovery,and reduce compli cations.

关 键 词：有创-无创呼吸机序贯机械通气 肺表面活性剂 早产儿 呼吸窘迫综合征 

分 类 号：R725.6[医药卫生—儿科]