N-乙酰半胱氨酸雾化吸入联合多沙普仑治疗慢性阻塞性肺疾病急性加重期伴呼吸衰竭  

N-acetylcysteine aerosol inhalation combined with doxapram in the treatment of AECOPD with respiratory failure

作　　者：李淑勤 LI Shuqin(Department of Clinical Medicine,Fenyang College,Shanxi Medical University,Lvliang 032200,China)

机构地区：[1]山西医科大学汾阳学院临床医学系,山西吕梁032200

出　　处：《中国处方药》2024年第11期114-117,共4页Journal of China Prescription Drug

摘　　要：目的 探讨N-乙酰半胱氨酸(NAC)雾化吸入联合多沙普仑治疗慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭的疗效。方法 选择2021年10月~2023年9月收治的AECOPD伴呼吸衰竭患者85例为研究对象,随机分为两组,对照组(42例)在常规治疗基础上给予NAC雾化吸入治疗,观察组(43例)在对照组基础上加以多沙普仑静脉滴注治疗。评估治疗后两组临床疗效,比较治疗前后两组血气分析指标[动脉血氧分压(PaO_(2))、氧合指数(OI)、动脉血二氧化碳分压(PaCO_(2))]、呼吸频率、潮气量和分钟通气量、炎症因子[超敏-C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]变化水平,统计治疗过程中两组不良反应发生情况。结果 治疗后观察组总有效率、OI、PaO_(2)、潮气量、分钟通气量高于对照组(P <0.05),PaCO_(2)、IL-8、TNF-α、hs-CRP、呼吸频率均低于对照组(P <0.05),治疗过程中两组不良反应比较,差异无统计学意义(P> 0.05)。结论 NAC雾化吸入联合多沙普仑治疗AECOPD伴呼吸衰竭患者可明显提升疗效,有效降低炎症反应,改善肺功能,安全可靠。Objective To explore the curative effect of N-acetylcysteine(NAC)aerosol inhalation combined with doxapram in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Methods A total of 85 patients with AECOPD and respiratory failure admitted from October 2021 and September 2023 were randomly divided into two groups.The control group(42 cases)was treated with NAC aerosol inhalation on the basis of routine treatment,and the observation group(43 cases)was treated with intravenous drip of doxapram on the basis of the control group.The clinical curative effect of the two groups was evaluated after treatment.The changes in blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),oxygenation index(OI),arterial partial pressure of carbon dioxide(PaCO_(2))],respiratory rate,tidal volume,minute ventilation volume and inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]before and after treatment in the two groups were compared.The occurrence of adverse reactions in the two groups was statistically analyzed during treatment.Results After treatment,the total effective rate,OI,PaO_(2),tidal volume,minute ventilation volume were higher in the observation group than those in the control group(P<0.05),while PaCO_(2),IL-8,TNF-α,hs-CRP and respiratory rate were lower in the observation group than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups during treatment(P>0.05).Conclusion NAC aerosol inhalation combined with doxapram can significantly improve curative effect,effectively reduce inflammatory response,improve pulmonary function in the treatmant of patients with AECOPD and respiratory failure,which is safe and reliable.

关 键 词：N-乙酰半胱氨酸 多沙普仑 慢性阻塞性肺疾病急性加重期 呼吸衰竭 

分 类 号：R563.9[医药卫生—呼吸系统] R563.8[医药卫生—内科学]