氨甲环酸在预防初产妇阴道分娩产后出血的价值分析  

Analysis of the value of tranexamic acid in preventing postpartum hemorrhage of primipara after vaginal delivery

作　　者：毕恒 蒋翠 黄瑶 BI Heng;JIANG Cui;HUANG Yao(Department of Obstetrics,Changde Maternal and Child Health Hospital,Changde 415000,China)

机构地区：[1]常德市妇幼保健院产科,湖南常德415000

出　　处：《中国处方药》2024年第11期149-151,共3页Journal of China Prescription Drug

摘　　要：目的 分析氨甲环酸在预防初产妇阴道分娩产后出血的价值。方法 选取医院2022年1月~2023年8月纳入的62例经阴道分娩初产妇,按照随机数字法分为对照组(n=31)和观察组(n=31),其中对照组采用缩宫素治疗,观察组在缩宫素的基础上采用氨甲环酸治疗。评估两组出血情况、凝血功能指标、临床情况和不良反应。结果 治疗后,与对照组相比,观察组的产后2 h出血量、产后24 h出血量和产后出血发生率均明显更优(P <0.05)。治疗后,与对照组相比,观察组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平均明显更低(P <0.05),观察组的纤维蛋白原(FIB)水平明显更高(P <0.05)。治疗后,与对照组相比,观察组的子宫底下降速度和子宫收缩持续时间均明显更优(P <0.05)。治疗后,两组不良反应发生率相比,差异无统计学意义(P> 0.05)。结论 氨甲环酸预防初产妇阴道分娩产后出血效果显著,可以改善产妇的凝血功能指标,降低产妇的产后出血情况,从而促进产妇产后恢复。Objective To analyze the value of tranexamic acid in preventing postpartum hemorrhage of primipara after vaginal delivery.Methods A total of 62 first-time women who gave birth vaginally from January 2022 to August 2023 were selected and divided into the control group(n=31)and the observation group(n=31)according to the random number method,in which the control group was treated with oxytocin,and the observation group was treated with tranexamic acid on the basis of oxytocin.The bleeding conditions,coagulation function indicators,clinical conditions and adverse reactions were evaluated in the two groups.Results After treatment,compared with the control group,the blood loss of 2 h,24 h and the incidence of postpartum hemorrhage in the observation group were significantly better(P<0.05).After treatment,compared with the control group,the PT and APTT levels in the observation group were significantly lower(P<0.05),and the FIB level in the observation group was significantly higher(P<0.05).After treatment,the descending rate of uterine floor and duration of uterine contraction in the observation group were significantly better than those in the control group(P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tranexamic acid has a significant effect in preventing postpartum hemorrhage during vaginal delivery,which can improve the coagulation function of pregnant women,reduce postpartum hemorrhage,and promote postpartum recovery.

关 键 词：氨甲环酸 初产妇 阴道分娩 产后出血 应用价值 

分 类 号：R714.461[医药卫生—妇产科学]