活血清胰汤保留灌肠联合乌司他丁治疗急性胰腺炎患者的效果  

Effects of Huoxue Qingyi decoction retention enema combined with Ulinastatin in treatment of patients with acute pancreatitis

作　　者：李秀 刘晓东 LI Xiu;LIU Xiaodong(Jingbian County People's Hospital,General Medicine Department,Yulin 718500 Shaanxi,China;Jingbian County People's Hospital,Emergency Center,Yulin 718500 Shaanxi,China)

机构地区：[1]靖边县人民医院全科医学科,陕西榆林718500 [2]靖边县人民医院急救中心,陕西榆林718500

出　　处：《中国民康医学》2024年第22期96-99,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察活血清胰汤保留灌肠联合乌司他丁治疗急性胰腺炎患者的效果。方法:回顾性分析2020年1月至2024年1月该院收治的156例急性胰腺炎患者的临床资料,按照治疗方法不同将其分为研究组与对照组各78例。对照组采用乌司他丁注射液治疗,研究组在对照组基础上联合活血清胰汤保留灌肠治疗,比较两组临床疗效,治疗前后胃肠激素指标[促胃动素(MTL)、肠抑胃肽(GIP)、胃肠激素活动性肠肽(VIP)]水平、疾病相关指标[血清淀粉酶(AMS)、转化生长因子-β(TGF-β)]水平、中医证候积分、炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:研究组治疗总有效率为93.59%(73/78),高于对照组的83.33%(65/78),差异有统计学意义(P<0.05);治疗后,两组GIP、VIP水平均低于治疗前,且研究组低于对照组,两组MTL水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组AMS水平均低于治疗前,且研究组低于对照组,两组TGF-β水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组腹胁钻痛、恶心呕吐、胸闷腹胀等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组TNF-α、IL-6、CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:活血清胰汤保留灌肠联合乌司他丁治疗急性胰腺炎患者可提高治疗总有效率,改善胃肠激素指标和疾病相关指标水平,以及降低中医证候积分和炎性因子水平的效果优于单纯乌司他丁注射液治疗。Objective:To observe effects of Huoxue Qingyi decoction retention enema combined with Ulinastatin in treatment of patients with acute pancreatitis.Methods:The clinical data of 156 patients with acute pancreatitis admitted to this hospital from January 2020 to January 2024 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,78 cases in each group.The control group was treated with Ulinastatin injection,while the study group was treated with Huoxue Qingyi decoction retention enema on the basis of that of the control group.The clinical efficacy,the gastrointestinal hormone indexes[motilin(MTL),intestinal inhibitory peptide(GIP),gastrointestinal hormone active intestinal peptide(VIP)]levels,the disease-related indexes[serum amylase(AMS),transforming growth factor-β(TGF-β)]levels,the TCM syndrome scores,the inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 93.59%(73/78),which was higher than 83.33%(65/78)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of GIP and VIP in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the MTL levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the difference was statistically significant(P<0.05).After the treatment,the AMS levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the levels of TGF-βin the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the difference was statistically significant(P<0.05).The scor

关 键 词：活血清胰汤 保留灌肠 乌司他丁 急性胰腺炎 胃肠激素 中医证候积分 炎性因子 

分 类 号：R657.5[医药卫生—外科学]