心血管衰老机制:蛋白稳态丧失、基因组不稳定性及炎症  

Cardiovascular aging mechanism:loss of protein homeostasis,genomic instability and inflammation

作　　者：郑刚 ZHENG Gang(Internet Hospital,Teda Interational Cardiovascular Hospital,Tianjin 300457,China)

机构地区：[1]泰达国际心血管病医院互联网医院,天津300457

出　　处：《世界临床药物》2024年第10期1016-1022,共7页World Clinical Drug

摘　　要：蛋白稳态丧失、基因组不稳定及炎症三者均参与心血管衰老,而心血管衰老与动脉粥样硬化(atherosclerosis)、心力衰竭(heart failure)及心肌病等多种心血管疾病的发生、发展密切相关。故蛋白稳态、基因组稳定性及炎症可能是衰老相关心血管疾病的治疗靶点。该文简要综述蛋白稳态丧失、基因组不稳定及炎症在心血管衰老中的作用机制,以期为今后心血管疾病的预防、诊断及新药研发提供新方向。Loss of protein homeostasis,genomic instability and inflammation all involve in cardiovascular aging,and which is closely related to the occurrence and development of cardiovascular diseases,such as atherosclerosis,heart failure,cardiomyopathy and other.Therefore,protein homeostasis,genomic stability,and inflammation may be therapeutic targets for age-related cardiovascular diseases.This article reviewed the mechanisms of protein homeostasis loss,genomic instability,and inflammation in cardiovascular aging,in order to provide new directions for the prevention,diagnosis,and development of new drugs for cardiovascular diseases in the future.

关 键 词：心血管系统 衰老 蛋白稳态丧失 基因组不稳定 炎症 

分 类 号：R543[医药卫生—心血管疾病]