克感利咽口服液用于儿童上呼吸道系统疾病的临床分析  

Clinical analysis of rheum and pharyngitis oral solution for upper respiratory system diseases in children

作　　者：伍柏坚 黄腾[2] 谢君 鲁培[3] 彭绍忠 黄晓丹 WU Bojian;HUANG Teng;XIE Jun;LU Pei;PENG Shaozhong;HUANG Xiaodan(Guangzhou Wanglaoji Pharmaceutical Company Limited,Guangzhou/Guangdong Provincial Key Laboratory of Famous Chinese Medicine and Liang Cha(Herbal Beverage),Guangzhou 510450,Guangdong Province,China;Department of Pediatrics,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 511400,Guangdong Province,China;Department of Pharmaceutical,Guangdong Women's and Children's Hospital,Guangzhou 510030,Guangdong Province,China)

机构地区：[1]广州王老吉药业股份有限公司/广东省名优中成药与凉茶企业重点实验室,广东广州510450 [2]广东省中医院儿科,广东广州511400 [3]广东省妇幼保健院药学部,广东广州510030

出　　处：《世界临床药物》2024年第10期1085-1090,共6页World Clinical Drug

摘　　要：目的通过多中心回顾性研究,了解克感利咽口服液在真实世界中对儿童上呼吸道系统疾病的临床疗效与安全性,以及不良反应与用药方案的相关性。方法采集2016年5月31日至2022年5月31日在目标中心就诊的处方使用克感利咽口服液的500例患儿病历信息,分析其年龄、性别、就诊科室、诊疗目的、用药情况、实验室检查结果及合并用药信息。结果患儿平均年龄为(7.80±3.45)岁,6岁以上用药人群占比56%,3~6岁人群次之(44.00%)。就诊人数最高的科室为儿科(57.14%)。使用克感利咽口服液占比最高的疾病为急性上呼吸道感染(89.20%),克感利咽口服液联合用药种类中占比最高的为中药(39.80%)。两个年龄段单次服药剂量、服药天数、每日服药总剂量以及服药周期总剂量差异显著(P<0.05)。患儿首次检查和末次检查间的血常规、C-反应蛋白以及肾功能指标结果无显著差异(P>0.05)。结论克感利咽口服液目前仍以儿童上呼吸道系统疾病辅助治疗为主,临床医生对克感利咽口服液疗效的认可度高。Objective To investigate the clinical efficacy and safety of rheum and pharyngitis oral solution in the treatment of upper respiratory system diseases in children in the real world,and to analyze the correlation between adverse reactions and medication regimen through multi-center retrospective study.Methods The medical records of 500 children using rheum and pharyngitis oral solution in target centers from May 31,2016 to May 31,2022 were collected,and their age,gender,department of treatment,purpose of diagnosis and treatment,drug use,laboratory test results and drug combination information were analyzed.Results The mean age of the patients was(7.80±3.45)years old.The patients above 6 years old accounted for 56%,followed by the patients between 3 and 6 years old(44.00%).The department with the highest number of patients was pediatrics(57.14%).Acute upper respiratory tract infection(89.20%)was the highest proportion of rheum and pharyngitis oral solution,and Chinese medicine(39.80%)was the highest proportion of rheum and pharyngitis oral solution combined drugs.There were significant differences in single dose,days of medication,total daily dose and total dose of medication cycle between the two age groups(P<0.05).There were no significant differences in blood routine,C-reactive protein and renal function indexes between the first examination and the last examination(P>0.05).Conclusion At present,rheum and pharyngitis oral solution is mainly used in the adjuvant treatment of upper respiratory system diseases in children,and the efficacy of rheum and pharyngitis oral solution is highly recognized by clinicians.

关 键 词：克感利咽口服液 儿童 上呼吸道感染 

分 类 号：R276.1[医药卫生—中医五官科学] R725.6[医药卫生—中医学]