麝香保心丸对冠心病心绞痛患者冠脉血流及心率变异性的影响  

Influence of Shexiang Baoxin Pills for Coronary Blood Flow and Heart Rate Variability of Patients with Angina Pectoris Caused by Coronary Heart Disease

作　　者：王康力[1] WANG Kangli(Changzhou Third People's Hospital,Changzhou 213000,China)

机构地区：[1]常州市第三人民医院,江苏常州213000

出　　处：《中外医学研究》2024年第32期41-45,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究麝香保心丸对冠心病心绞痛患者冠脉血流及心率变异性的影响。方法:选取2021年11月-2023年6月常州市第三人民医院收治的110例冠心病心绞痛患者。根据随机数表法将其分为对照组(55例)和观察组(55例)。对照组给予常规冠心病心绞痛治疗,观察组在对照组基础上给予麝香保心丸。比较两组治疗后临床疗效,不良反应,治疗前、治疗2周及4周后冠脉血流指标、心率变异性。结果:观察组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗2周及4周后,观察组收缩期峰流速(SPV)、舒张期峰流速(DPV)及时间速度积分(CTVI)均显著高于对照组,治疗4周后,两组SPV、DPV及CTVI均显著高于治疗前及治疗2周后,治疗2周后,两组SPV、DPV及CTVI均显著高于治疗前,差异有统计学意义(P<0.05)。治疗2周及4周后,观察组全部正常窦性心搏间期的标准差(SDNN)、RR间期平均值标准差(SDANN)、相邻的RR间期差值>50 ms者占分析总心搏数量的百分比(PNN50)及相邻RR间期差值的均方根(RMSSD)均显著高于对照组,治疗4周后,两组SDNN、SDANN、PNN50、RMSSD均显著高于治疗前及治疗2周后,治疗2周后,两组SDNN、SDANN、PNN50、RMSSD均显著高于治疗前,差异有统计学意义(P<0.05)。治疗2周及4周后,观察组低频功率(LF)及高频功率(HF)均显著高于对照组,治疗4周后,两组LF、HF均显著高于治疗前及治疗2周后,治疗2周后,两组LF、HF均显著高于治疗前,差异有统计学意义(P<0.05)。结论:麝香保心丸在冠心病心绞痛患者中的应用效果较好,且可显著改善患者的冠脉血流及心率变异性。Objective:To investigate the influence of Shexiang Baoxin Pills for coronary blood flow and heart rate variability of patients with angina pectoris caused by coronary heart disease.Method:A total of 110 patients with angina pectoris of coronary heart disease treated in Changzhou Third People's Hospital from November 2021 to June 2023 were selected.They were divided into control group(55 cases)and observation group(55 cases)according to random number table method.The control group was given conventional treatment of coronary heart disease and angina pectoris,and the observation group was given Shexiang Baoxin Pill on the basis of the control group.The clinical efficacy,adverse reactions,coronary blood flow index and heart rate variability before treatment,after 2 weeks and 4 weeks of treatment were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 2 weeks and 4 weeks of treatment,systolic peak flow velocity(SPV),diastolic peak flow velocity(DPV)and time velocity integral(CTVI)in observation group were significantly higher than those in control group;after 4 weeks of treatment,SPV,DPV and CTVI in both groups were significantly higher than those before treatment,2 weeks after treatment,and 2 weeks after treatment.SPV,DPV and CTVI in the two groups were significantly higher than those before treatment,the differences were statistically significant(P<0.05).After 2 weeks and 4 weeks of treatment,the standard deviation of all normal sinus intervals(SDNN),the standard deviation of the average RR interval(SDANN),the percentage of adjacent RR interval differences>50 ms in the total number of analyzed heartbeats(PNN50),and the root mean square of adjacent RR interval differences(RMSSD)in the observation group were significantly higher than those in the control group

关 键 词：麝香保心丸 冠心病心绞痛 冠脉血流 心率变异性 

分 类 号：R256.22[医药卫生—中医内科学]