宫腔镜子宫纵隔切除术中应用不同剂量羟考酮联合丙泊酚行麻醉诱导的临床效果  

Clinical Effect of Anesthesia Induction Using Different Doses of Oxycodone Combined with Propofol in Hysteroscopic Mediastinal Hysterectomy

作　　者：张修德 张琦 万基正 ZHANG Xiude;ZHANG Qi;WAN Jizheng(Yanggu County People's Hospital,Yanggu 252300,China;不详)

机构地区：[1]阳谷县人民医院,山东阳谷252300

出　　处：《中外医学研究》2024年第32期53-56,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨宫腔镜子宫纵隔切除术中应用不同剂量羟考酮联合丙泊酚行麻醉诱导的临床效果。方法:选取2019年1月-2022年12月于阳谷县人民医院行宫腔镜子宫纵隔切除术的100例患者。按照随机数表法将患者分为对照组(n=25)、低剂量组(n=25)、中剂量组(n=25)、高剂量组(n=25),对照组给予0.9%氯化钠注射液联合丙泊酚,低剂量组给予羟考酮(0.05 mg/kg)联合丙泊酚,中剂量组给予羟考酮(0.10 mg/kg)联合丙泊酚,高剂量组给予羟考酮(0.15 mg/kg)联合丙泊酚。对比四组患者手术指标(丙泊酚诱导量、丙泊酚维持量、苏醒时间)、苏醒后各时间段视觉模拟评分法(VAS)评分、不同时间的平均动脉压(MAP)、心率(HR)及不良反应发生情况。结果:高剂量组丙泊酚诱导量低于中剂量组、低剂量组和对照组,中剂量组低于低剂量组和对照组,差异有统计学意义(P<0.05);对照组与低剂量组丙泊酚诱导量比较,差异无统计学意义(P>0.05);高剂量组苏醒时间长于中剂量组,但短于低剂量组和对照组,中剂量组苏醒时间短于低剂量组和对照组,低剂量组短于对照组,差异有统计学意义(P<0.05)。苏醒时、苏醒后1 h、苏醒后2 h,高剂量组和中剂量组的VAS评分均低于低剂量组和对照组,低剂量组低于对照组,差异有统计学意义(P<0.05)。四组不同时间MAP、HR比较,差异无统计学意义(P>0.05)。高剂量组低氧血症发生率高于中剂量组、低剂量组、对照组,头晕发生率高于对照组,差异有统计学意义(P<0.05)。结论:0.10 mg/kg羟考酮联合丙泊酚在宫腔镜子宫纵隔切除术中麻醉诱导效果最佳。Objective:To explore the clinical effect of anesthesia induction using different doses of Oxycodone combined with Propofol in hysteroscopic mediastinal hysterectomy.Method:A total of 100 patients who underwent hysteroscopic mediastinal hysterectomy in Yanggu County People's Hospital from January 2019 to December 2022 were selected.According to the random number table method,the above patients were divided into control group(n=25),low-dose group(n=25),medium dose group(n=25),and high-dose group(n=25).The control group received Sodium Chloride Injection combined with Propofol,the low-dose group received Oxycodone(0.05 mg/kg)combined with Propofol,the medium dose group received Oxycodone(0.10 mg/kg)combined with Propofol,and the high-dose group received Oxycodone(0.15 mg/kg)combined with Propofol.The surgical indicators(Propofol induction volume,Propofol maintenance volume,and awakening time),visual analogue scale(VAS)scores at different time periods after awakening,mean arterial pressure(MAP),heart rate(HR),and adverse reactions among four groups of patients were compared.Result:The induced dose of propofol in high-dose group was lower than that in medium-dose group,low-dose group and control group,and the medium-dose group was lower than that in low-dose group and control group,the differences were statistically significant(P<0.05).There was no significant difference in the induced dose of propofol between control group and low-dose group(P>0.05).The recovery time of the high-dose group was longer than that of the medium-dose group,but shorter than that of the low-dose group and the control group,the recovery time of the medium-dose group was shorter than that of the low-dose group and the control group,and the differences were statistically significant(P<0.05).At the time of recovery,1 h after recovery,2 h after recovery,the VAS scores of the high-dose group and the medium-dose group were lower than those of the low-dose group and the control group,and the differences were statistically significant(P<0.05).There

关 键 词：宫腔镜子宫纵隔切除术 羟考酮 丙泊酚 麻醉诱导 临床效果 

分 类 号：R614[医药卫生—麻醉学]