慢性肾脏病3~5期患者凝血功能变化及高凝状态危险因素分析  

Analysis of Coagulation Function Changes and Risk Factors for Hypercoagulability in Patients with Chronic Kidney Disease in Stages 3-5

作　　者：邱素娟[1] 陈文青 QIU Sujuan;CHEN Wenqing(The First Hospital of Xiamen University,Xiamen 361000,China;不详)

机构地区：[1]厦门大学附属第一医院,福建厦门361000

出　　处：《中外医学研究》2024年第32期79-82,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析慢性肾脏病(CKD)3~5期患者凝血功能变化及高凝状态危险因素。方法:选取2019年1月-2024年1月厦门大学附属第一医院收治的105例CKD 3~5期患者作为CKD组,另选取同期55例体检健康志愿者作为对照组。收集CKD组一般资料。检测两组实验室指标。对CKD组进行分组。分析分组情况,比较三组凝血酶原时间(PT)、凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)。比较高凝状态组和非高凝状态组一般资料及实验室指标。分析CKD 3~5期患者高凝状态危险因素。结果:CKD高凝状态组40例,非高凝状态组65例。高凝状态组PT、APTT、TT均短于非高凝状态组及对照组,FIB水平高于非高凝状态组及对照组,非高凝状态组PT、APTT、TT均短于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05)。高凝状态组血肌酐(Scr)、C反应蛋白(CRP)水平均高于非高凝状态组,估算肾小球滤过率(eGFR)、血红蛋白(Hb)水平均低于非高凝状态组,差异有统计学意义(P<0.05)。CRP是影响CKD 3~5期患者高凝状态的危险因素,而eGFR、Hb则是CKD 3~5期患者高凝状态的保护因素(P<0.05)。结论:CKD 3~5期患者存在凝血功能紊乱,且eGFR、CRP及Hb水平是影响患者高凝状态的因素,临床应加强上述指标监测,以预防高凝状态的发生。Objective:To analyze the coagulation function changes and risk factors for hypercoagulability in patients with chronic kidney disease(CKD)in stages 3-5.Method:A total of 105 CKD stage 3-5 patients admitted to the First Hospital of Xiamen University from January 2019 to January 2024 were selected as the CKD group,and 55 healthy volunteers who underwent physical examinations during the same period were selected as the control group.The general information of CKD group was collected.Laboratory indicators of two groups were detected.CKD group was divided into groups.The grouping situation was analyzed and the prothrombin time(PT),thromboplastin time(APTT),thrombin time(TT),and fibrinogen(FIB)of the three groups was compared.The general information and laboratory indicators between the high coagulation state group and the non high coagulation state group was compared.The risk factors for hypercoagulability in CKD stage 3-5 patients was analyzed.Result:There were 40 cases in the CKD hypercoagulable state group and 65 cases in the CKD non hypercoagulable state group.The PT,APTT,and TT in the CKD hypercoagulable state group were shorter than those in the CKD non hypercoagulable state group and the control group,and the FIB level was higher than that in the CKD non hypercoagulable state group and the control group,the PT,APTT,and TT in the CKD non hypercoagulable state group were shorter than those in the control group,and the FIB level was higher than that in the control group,the differences were statistically significant(P<0.05).The levels of creatinine(Scr)and C-reactive protein(CRP)in the CKD hypercoagulable state group were higher than those in the CKD non hypercoagulable state group,the estimated glomerular filtration rate(eGFR)and hemoglobin(Hb)levels were lower than those in the CKD non hypercoagulable state group,and the differences were statistically significant(P<0.05).CRP was the risk factor for hypercoagulability in CKD stage 3-5 patients,while eGFR and Hb were protective factors for hypercoagulability in CK

关 键 词：慢性肾脏病 高凝状态 凝血功能 危险因素 

分 类 号：R692[医药卫生—泌尿科学]