Association of Di(2-ethylhexyl)Phthalate Exposure with Reproductive Hormones in the General Population and the Susceptible Population:A Systematic Review and Meta-Analysis  

作　　者：Xuanxuan Li Changchun Xiao Jintao Liu Ning Wei Jian Song Jiajun Yuan Li Liu Rong Song Weizhuo Yi Rubing Pan Jian Cheng Shusi Wang Hong Su 

机构地区：[1]Department of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China [2]Center for Big Data and Population Health of IHM,Hefei,Anhui 230032,China [3]Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei,Anhui 230032,China [4]Hefei Center for Disease Control and Prevention,Hefei,Anhui 230032,China [5]Department of Healthcare-associated Infection Management,Hefei Stomatological Hospital,Anhui Medical University Hefei Oral Clinic College,Hefei 230032,China

出　　处：《Environment & Health》2024年第11期750-765,共16页环境与健康（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.42375184 and 42105165);Research Funds of Center for Big Data and Population Health of IHM(Grant No.JKS2022011);Natural Science Research Key Project of University of Anhui Province(Grant No.2023AH050652).

摘　　要：Di(2-ethylhexyl)phthalate(DEHP),an environ-mental endocrine disruptor,has hormone-like activity and endocrine-disrupting effects.However,the types of reproductive hormones associated with DEHP vary across the studies.Thus,we conducted a systematic review and meta-analysis to pool existing epidemiological evidence.We searched three databases up to January 31,2024,for eligible original studies to ultimately include 37 studies from eight countries with a total of 28911 participants.DEHP exposure was evaluated with urinary metabolites.Since the main types,production sites,blood concentrations,and functions of reproductive hormones differ between men and women,we reported the combined effect values by gender.Subgroup analyses were conducted by age,subfertility status,and the national sociodemographic index(SDI)level.Furthermore,the effect of maternal exposure during pregnancy on children’s reproductive hormone levels was analyzed separately.Overall,in general,in men,DEHP was positively correlated with sex hormone binding-globulin(SHBG)and adversely correlated with total testosterone(TT),free androgen index(FAI),and follicle-stimulating hormone(FSH).Results indicated that among men of reproductive age,DEHP exposure was associated with more significant hormonal suppression in infertile men compared with fertile men.Notably,age subgroup analysis among women revealed that postmenopausal women were more vulnerable to DEHP,which was related to lower TT and estradiol(E2).However,this study did not observe a significant association between prenatal DEHP metabolites and reproductive hormone levels in children.Our research identifies the most susceptible hormones(androgen suppression)after DEHP exposure and suggests that infertile men and postmenopausal women are in great need of more attention as sensitive populations.

关 键 词：Di(2-ethylhexyl)phthalate DEHP Reproductive hormones Endocrine disruptors META-ANALYSIS 

分 类 号：R12[医药卫生—环境卫生学]