Establishing a Multifaceted Comprehensive Maternity Cohort Facilitates Understanding of How Environmental Exposures Impact Perinatal Health  

作　　者：Haitong Zhe Sun Haiyang Tang Qingyi Xiang Siyuan Xu Yijia Tian Huan Zhao Jing Fang Haizhen Dai Rui Shi Yuxia Pan Ting Luo Hangbiao Jin Chenyang Ji Yuanchen Chen Hengyi Liu Meirong Zhao Kun Tang Sheena Nishanti Ramasamy Evelyn Xiu-Ling Loo Lynette P.Shek Yuming Guo Wei Xu Xiaoxia Bai 

机构地区：[1]Centre for Sustainable Medicine,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117609,Republic of Singapore [2]Department of Paediatrics,Yong Loo Lin School of Medicine and Saw Swee Hock School of Public Health,National University of Singapore,Singapore 117609,Republic of Singapore [3]Department of Obstetrics,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310006,PR China [4]Yusuf Hamied Department of Chemistry,University of Cambridge,Cambridge CB21EW,United Kingdom [5]Department of Earth Sciences,University of Cambridge,Cambridge CB23EQ,United Kingdom [6]Department of Obstetrics and Gynecology,The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu,Zhejiang 322000,PR China [7]Wenling Women’s and Children’s Hospital,Taizhou,Zhejiang 317500,PR China [8]Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province,College of Environment,Zhejiang University of Technology,Hangzhou,Zhejiang 310032,PR China [9]Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province,Interdisciplinary Research Academy,Zhejiang Shuren University,Hangzhou,Zhejiang 310006,PR China [10]Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health,School of Public Health,Peking University Health Science Centre,Beijing 100191,PR China [11]Vanke School of Public Health,Tsinghua University,Beijing 100084,PR China [12]Department of Paediatrics,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117609,Republic of Singapore [13]Department of Paediatrics,Yong Loo Lin School of Medicine and Human Potential Translational Research Programme,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117609,Republic of Singapore [14]Singapore Institute for Clinical Sciences(SICS),Agency for Science,Technology and Research(A^(*)STAR),Singapore 117609,Republic of Singapore [15]School of Public Health and Preventive Medicine,Monash Univ

出　　处：《Environment & Health》2024年第11期766-775,共10页环境与健康（英文）

基　　金：funding from various sources,including the Zhejiang Province Health Innovative Talent Project(A0466);the International Cooperation Seed Program of Women’s Hospital,Zhejiang University(GH2022B008-01 and GH2024005);the Australian Research Council(DP210102076);the Australian National Health and Medical Research Council(APP2000581);the UK Research and Innovation(UKRI)Centre for Application of Artificial Intelligence to the Study of Environmental Risks(AI4ER,EP/S022961/1);the Start-up Grant from Yong Loo Lin School of Medicine,National University of Singapore(NUHSRO/2024/045/Startup/06),and the US-China Fulbright Program.

摘　　要：China’s“three-child policy”,implemented in response to population aging,has made the protection of maternal and infant health an urgent priority.In this environmental and medical big-data era,the Zhejiang Environmental and Birth Health Research Alliance(ZEBRA)maternity cohort was established with the aim of identifying risk factors for perinatal morbidity and mortality from the perspectives of both observational epidemiology and experimental etiology.Compared with conventional birth cohorts,the inclusion of a maternity cohort allows greater scope for research and places an emphasis on maternal health.In particular,it allows us to focus on pregnant women with a history of pregnancy-related illnesses and those planning to have a second or third child.There are currently many pressing issues in perinatal health,including the risk associations between exogenous together with endogenous factors and the occurrence of perinatal abnormalities,pregnancy complications,and adverse pregnancy outcomes.It is crucial to explore the interaction between environmental exposures and genetic factors affecting perinatal health if we are to improve it.It is also worthwhile to assess the feasibility of the early stage prediction of major perinatal abnormalities.We hope to study this in the ZEBRA cohort and also seek nationwide and international collaborations to establish a multicenter cohort consortium,with the ultimate goal of contributing epidemiological evidence to literature and providing evidence-based insights for global maternal and child healthcare.

关 键 词：cohort profile prospective maternity cohort perinatal health PRE-ECLAMPSIA preterm birth low birth weight environmental exposure 

分 类 号：R71[医药卫生—妇产科学]