Maternal Thyroid Hormones as Mediators between Phthalate Exposure and Neonatal Birth Weight:A Cross-Sectional Study from the Zunyi Birth Cohort  

作　　者：Lin Tao Dengqing Liao Shimin Xiong Lulu Dai Yuan-zhong Zhou Xubo Shen 

机构地区：[1]School of Public Health,Zunyi Medical University,Zunyi,Guizhou Province 563000,China [2]Key Laboratory of Maternal&Child Health and Exposure Science of Guizhou Higher Education Institutes,Zunyi,Guizhou Province 563000,China

出　　处：《Environment & Health》2024年第11期816-826,共11页环境与健康（英文）

基　　金：funded by the National Key Research and Development Program of China(2018YF-C1004300,2018YFC1004302);Science&Technology Program of Guizhou Province(QKHHBZ[2020]3002,QKHPTRC-GCC[2022]039-1,QKHPTRC-CXTD[2022]014);Natural Science Foundation of Guizhou Province(QKH-J[2022]YB614);Science and Technology Plan Project of Zunyi City(ZKH-J(2021)294).

摘　　要：Studies have shown that exposure to phthalates can affect neonatal birth weight.However,epidemiological evidence on the mediating role of maternal thyroid hormones is limited.Therefore,this study,based on the Compliance Birth Cohort,aimed to reveal the potential mediating function of maternal thyroid hormones during pregnancy between phthalic acid ester(PAE)exposure and neonatal birth weight.The study included 1274 mother−infant pairs.Linear regression analysis revealed a negative association between MIBP and neonatal birth weight(β=−62.236;95%CI:−118.842,−5.631).Bayesian kernel-machine regression(BKMR)indicated a nonlinear negative association between PAE metabolites(PAEs)and birth weight.Linear regression analysis revealed a positive association between neonatal birth weight and FT3(β=41.605;95%CI:2.631,80.380).The BKMR model also found a positive association between thyroid hormones and birth weight but in a nonlinear manner.Additionally,linear regression analyses showed that TSH,TT3,TT4,FT3,and FT4 were associated with PAEs.The BKMR model revealed an inverted U-shaped association of PAEs with TT3 and FT3 and a nonlinear association with TSH,TT4,and FT4.Structural equation modeling revealed that MMP,MIBP,MBP,MEHP,MOP,MBZP,and MEOHP contributed to a net reduction in neonatal birth weight of 32 g through the TT3,FT3,TT4,and FT4 pathways.The findings suggest that exposure to PAEs during pregnancy leads to a reduction in neonatal birth weight,possibly due to the involvement of maternal thyroid hormones as mediators.Controlling maternal thyroid hormone levels during pregnancy may be a viable method to reduce the harmful effects of phthalate exposure on the developing fetus.

关 键 词：Phthalic acid esters(PAEs) Newborn birth weight(BBW) Thyroid hormones Linear regression model(LRM) Bayesian kernel-mechanism regression(BKMR) Structural equation modeling(SEM) 

分 类 号：R722[医药卫生—儿科] R12[医药卫生—临床医学]