Viremia and clinical manifestations in acute febrile patients of Chikungunya infection during the 2016 CHIKV outbreak in Delhi,India  

作　　者：Rohit Sagar Siva Raghavendhar Vineet Jain Naushad Khan Anmol Chandele Ashok Kumar Patel Murali Kaja Pratima Ray Neera Kapoor 

机构地区：[1]Department of Biotechnology,School of Chemical and Life Sciences,Jamia Hamdard,New Delhi 110062,India [2]Department of Life Sciences,School of Sciences,IGNOU,New Delhi 110068,India [3]Kusuma School of Biological Sciences,Indian Institute of Technology,New Delhi 110016,India [4]HAH Centenary Hospital,Jamia Hamdard,New Delhi 110062,India [5]ICGEB-Emory Vaccine Center,ICGEB,New Delhi 110067,India [6]Department of Pediatrics,Emory University School of Medicine,30322 Atlanta,GA,USA

出　　处：《Infectious Medicine》2024年第1期39-44,共6页感染医学（英文）

摘　　要：Background:Chikungunya virus(CHIKV)is an infectious agent that caused several outbreaks among different countries and affected approximately 1.3 million Indian populations.It is transmitted by Aedes mosquito–either A.albopictus or A.aegypti.Generally,the clinical manifestations of CHIKV infection involve high-grade fever,joint pain,skin rashes,headache,and myalgia.The present study aims to investigate the relationship between the CHIKV virus load and clinical symptoms of the CHIKV infection so that better patient management can be done in the background of the CHIKV outbreak as there is no licensed anti-viral drug and approved vaccines available against CHIKV.Methods:CHIKV RTPCR positive samples(n=18)(Acute febrile patients having D.O.F≤7 days)were taken for the quantification of CHIKV viremia by Real-Time PCR.Clinical features of the febrile patients were recorded during the collection of blood samples.Results:The log mean virus load of 18 RT-PCR-positive samples was 1.3×10^(6) copies/mL(1.21×10^(3)–2.33×10^(8) copies/mL).Among the observed clinical features,the log mean virus load(CHIKV)of the patients without skin rash is higher than in the patients with skin rash(6.61 vs.5.5,P=0.0435).Conclusion:The conclusion of the study was that the patients with skin rashes had lower viral load and those without skin rashes had higher viral load.

关 键 词：CHIKV Clinical features Viral load Febrile patients OUTBREAK 

分 类 号：R51[医药卫生—内科学]