Life threatening rickettsiosis and the role of hemophagocytic lymphohistiocytosis syndrome(HLH):Case report of a 21-year-old woman  

作　　者：Marine Chancel Ali Dadban Adrien Chan Sui Ko Florence Dupont Anna Potereau Rodrigue Wankap Yoann Zerbib Jean-Philippe Lanoix 

机构地区：[1]Department of Infectious Diseases,Amiens University Hospital,Amiens 80054,France [2]Department of Dermatology,Amiens University Hospital,Amiens 80054,France [3]Intensive Care Department,Amiens University Hospital,Amiens 80054,France

出　　处：《Infectious Medicine》2024年第1期67-70,共4页感染医学（英文）

摘　　要：Hemophagocytic lymphohistiocytosis(HLH)syndrome is an uncontrolled activation of macrophages,causing multiorgan dysfunction.The prognosis depends on the cause and the delay of diagnosis and treatment.Several infections can cause HLH,including rickettsia,a gram-negative bacterium.The diagnosis of rickettsia is based on clinical signs,including fever,headache,rash and sometimes tick bite site.The importance of an early diagnosis of rickettsia is the key.We present a case of rickettsia infection complicated with severe HLH occurring in a 21-year-old woman.The diagnosis was confirmed by serology 4 weeks after admission.She was treated with immunoglobulin,corticosteroids,and doxycycline with a favorable outcome.

关 键 词：RICKETTSIOSIS RICKETTSIA Hemophagocytic lymphohistiocytosis syndrome 

分 类 号：R37[医药卫生—病原生物学]