Instability-Driven 3D bioprinting for engineering composite bio-inks  

作　　者：Jing Ma Cheng Qi Zhou Liu Si Meng Tiantian Kong 

机构地区：[1]Department of Biomedical Engineering,School of Medicine,Shenzhen University,Shenzhen,Guangdong 518000,China [2]Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering,College of Mechatronics and Control Engineering,Shenzhen University,Shenzhen,Guangdong 518000,China [3]College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen,Guangdong 518000,China [4]Department of Urology,Shenzhen Institute of Translational Medicine,The First Affiliated Hospital of Shenzhen University,Shenzhen Second People’s Hospital,Shenzhen,Guangdong 518037,China

出　　处：《Engineered Regeneration》2024年第3期350-360,共11页再生工程（英文）

基　　金：the National Natural Science Foundation of China(NSFC 22308219,22078197,52172283);the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A1515110246,2023A1515011827);the Shenzhen Science and Technology Progra(JCYJ20220818095801003,RCYX20221008092902010);the Shenzhen Natural Science Fund(the Stable Support Plan Program 20220810120421001);the Medical-Engineering Interdisciplinary Research Foundation of Shenzhen University.

摘　　要：Extrusion-based 3D bioprinting techniques are revolutionizing bioengineering by facilitating the creation of com-plex 3D microstructures.This review offers a thorough overview of extrusion-based 3D bioprinting methods,par-ticularly highlighting the innovative electric-assisted coil-write 3D bioprinting technology.The review begins by explicating the fundamental principles underlying various extrusion-based 3D bioprinting technologies.It covers the printing equipment composition,suitable materials for 3D bioprinting,and the latest breakthroughs in tech-nology.A critical aspect of this review is the in-depth comparison of the strengths and weaknesses associated with each 3D bioprinting approach.The electro-microfluidic extrusion method and the electric-assisted coil-write 3D bioprinting technology are highlighted.This advanced technology successfully overcomes the limitations of conventional extrusion-based methods,notably in the precise printing of intricately curved line structures with high resolution and speed.This method ingeniously integrates mechanical motion for creating microscale features with electrical coiling for sub-micron details,thus achieving remarkable printing speeds and structural complex-ity.This review concludes by exploring the potential applications and future advancements of this state-of-the-art technology.It underscores the ability of electric-assisted coil-write 3D bioprinting to develop pioneering materials and micro-devices for a variety of technological sectors,highlighting its transformative impact in bioengineering.

关 键 词：BIOPRINTING EXTRUSION COILING ELECTROSPINNING INSTABILITY 

分 类 号：TB33[一般工业技术—材料科学与工程]