Microalgae-based drug delivery systems in biomedical applications  

作　　者：Hui Huang Yutong Lang Shoujie Wang Min Zhou 

机构地区：[1]Eye Center,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310029,China [2]Institute of Translational Medicine,Zhejiang University,Hangzhou 310029,China [3]Plastic Surgery,The Fouthe Affiliated Hospital,Zhejiang University School of Medicine,Yiwu 322000,China [4]Zhejiang University-University of Edinburgh Institute(ZJU-UoE Institute),Zhejiang University,Haining 314400,China [5]The National Key Laboratory of Biobased Transportation Fuel Technology,Zhejiang University,Hangzhou 310027,China [6]ZJU-Etuoke Joint Research Centre,Zhejiang University,Haining,310029,China

出　　处：《Engineered Regeneration》2024年第3期361-374,共14页再生工程（英文）

基　　金：supported by the National Key R&D Program of China(2022YFA1104900);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002);the Binjiang Institute of Zhejiang University(ZY202205SMKY007);the Natural Science Foundation of Shandong Province(ZR2023ZD30).

摘　　要：Over decades of development,the modern drug delivery system continues to grapple with numerous challenges,including drug loading inefficiencies,issues of immunogenicity,and cytotoxicity.These limitations restrict its application across various systems.Microalgae,as a natural resource,are not only abundant in bioactive com-pounds but also possess multiple biological properties,including active surface,photosynthesis capabilities,and excellent biocompatibility.These attributes make microalgae highly promising as carriers for targeted drug de-livery,offering significant potential for the diagnosis and treatment of various diseases.Therefore,leveraging the exceptional properties of microalgae for drug delivery and optimizing their qualities is of paramount importance.This article focuses on elucidating the biological characteristics of microalgae and their applications in drug de-livery,with a particular emphasis on emerging strategies for efficient drug loading and precise targeted delivery.Microalgae,as a natural biomaterial,hold immense potential for both commercial and clinical applications.

关 键 词：MICROALGAE Drug delivery system Tumor hypoxia OXYGENATOR Microswimmer 

分 类 号：R318[医药卫生—生物医学工程]