Cross-talk between biometal ions and immune cells for bone repair  

作　　者：Shubo Liu Zhengjie Lin Wei Qiao Bin Chen Jie Shen 

机构地区：[1]Division of Orthopaedics and Traumatology,Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,PR China [2]D Printing Clinical Translational and Regenerative Medicine Center,Department of Stomatology,Shenzhen Qianhai Shekou Free Trade Zone Hospital,Shenzhen,PR China [3]Shenzhen Key Laboratory of Spine Surgery,Department of Spine Surgery,Peking University Shenzhen Hospital,Shenzhen,PR China [4]Applied Oral Sciences and Community Dental Care,Faculty of Dentistry,The University of Hong Kong,Hong Kong S.A.R.,PR China

出　　处：《Engineered Regeneration》2024年第3期375-408,共34页再生工程（英文）

基　　金：supported by National Natural Science Foundation of China(82002303,12272164,82201124);Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515011536,2021A1515220093,2022A1515011815,2023A1515011963);Shenzhen Science and Technology Innovation Committee Projects(Nos.SGDX20220530111405038,JCYJ20220530151608019);Scientific Research Foundation of Peking University Shenzhen hospital(Nos.KYQD2021064,and KYQD2022215);Health and Medical Research Fund(09201466);Collaborative Research Fund(C7003-22Y).

摘　　要：Biometal ions are crucial in the structure and function of living organisms and have extensively been employed to promote bone tissue regeneration.Nevertheless,the biological functions of biometal ions and the underlying mechanisms responsible for their pro-regenerative effects remain incompletely understood,since bone repair is an intricate physiological process involving multiple cell types and signals.Recent accomplishments in the osteoim-munological field have revealed the momentous involvement of the immune system in mediating the therapeutic effects of biometal ions.The inflammatory factors secreted by immune cells contribute to bone cell migration,activation,and proliferation.This review summarizes the immune system and its constituent cells,followed by the current perspective on immunomodulation during bone healing.Next,the physicochemical and physiological properties of various biometal ions,including lithium,sodium,potassium,magnesium,calcium,strontium,vana-dium,iron,cobalt,copper,and zinc,are thoroughly reviewed.In addition,the interactions between biometal ions,immune cells,and bone tissue are discussed,aiming to provide insights into the prospective development of novel approaches to bone tissue regeneration by harnessing the therapeutic potential of these biometal ions.

关 键 词：Metal ion Bone regeneration Bone repair Immune cell Osteo-immunomodulation 

分 类 号：R68[医药卫生—骨科学]