Recovering skin-nerve interaction by nanoscale metal-organic framework for diabetic ulcers healing  

作　　者：Xiuru Ji Jingwei Zhou Zengding Zhou Zeyang Liu Li Yan Yuhan Li Haiyan Guo Weijie Su Han Wang Dalong Ni 

机构地区：[1]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,No.197,Ruijin 2nd Rd,Shanghai,200025,PR China [2]Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,No.639,Zhizaoju Rd,Shanghai,200011,PR China [3]Department of Burn and Plastic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,No.197,Ruijin 2nd Rd,Shanghai,200025,PR China [4]Department of Dermatology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,No.197,Ruijin 2nd Rd,Shanghai,200025,PR China

出　　处：《Bioactive Materials》2024年第12期112-123,共12页生物活性材料（英文）

基　　金：the financial support from National Natural Science Foundation of China(Grant No.82372098 and 82104073);Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure(SKL202212SIC);Shanghai Science and Technology Commission/General Project of Natural Science Foundation of Shanghai in 2021(21ZR1440600).

摘　　要：Skin-nerve interaction plays an important role in promoting wound healing.However,in diabetic ulcers(DUs),the diabetic periphery neuropathy and excessive levels of reactive oxygen species(ROS)block skin-nerve interaction and further impede the DUs healing.Herein,we developed a nanoscale metal-organic framework loaded with nerve growth factor(NGF/Ce-UiO-66,denoted NGF/CU)for the treatment of DUs.The Ce-UiO-66(CU)was applied as an antioxidant to scavenge ROS and reduce the inflammatory response while the NGF aided in the recovery of cutaneous nerves to further promote DUs healing.Both in vitro and in vivo experiments revealed the effective ability of NGF/CU for DUs healing.Subsequent RNA sequencing analysis revealed the mechanism that NGF/CU can improve wound healing by inhibiting the NF-κB signaling pathway and recovering the neuroendocrine system of the skin.This strategy of nerve regulation will provide more ideas for the treatment of DUs and other organ injuries.

关 键 词：Diabetic ulcers Reactive oxygen species Metal-organic framework CERIUM NEUROENDOCRINE 

分 类 号：R587.1[医药卫生—内分泌]