Harnessing the power of artificial intelligence for human living organoid research  

作　　者：Hui Wang Xiangyang Li Xiaoyan You Guoping Zhao 

机构地区：[1]Master Lab for Innovative Application of Nature Products,National Center of Technology Innovation for Synthetic Biology,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences(CAS),Tianjin,300308,PR China [2]Henan Engineering Research Center of Food Microbiology,College of food and bioengineering,Henan University of Science and Technology,Luoyang,471023,PR China [3]Haihe Laboratory of Synthetic Biology,Tianjin,300308,PR China [4]CAS-Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,Shanghai,200032,PR China [5]CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,PR China [6]Engineering Laboratory for Nutrition,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai,200031,PR China

出　　处：《Bioactive Materials》2024年第12期140-164,共25页生物活性材料（英文）

基　　金：supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC-008);Strategic Priority Research Program of the Chinese Academy of Sciences(XDC 0110300);Major Project of Haihe Laboratory of Synthetic Biology(E2M9560201);National Natural Science Foundation of China(32301210&31200035);the China Postdoctoral Science Foundation(No.2022M713330).

摘　　要：As a powerful paradigm,artificial intelligence(AI)is rapidly impacting every aspect of our day-to-day life and scientific research through interdisciplinary transformations.Living human organoids(LOs)have a great potential for in vitro reshaping many aspects of in vivo true human organs,including organ development,disease occurrence,and drug responses.To date,AI has driven the revolutionary advances of human organoids in life science,precision medicine and pharmaceutical science in an unprecedented way.Herein,we provide a forward-looking review,the frontiers of LOs,covering the engineered construction strategies and multidisciplinary technologies for developing LOs,highlighting the cutting-edge achievements and the prospective applications of AI in LOs,particularly in biological study,disease occurrence,disease diagnosis and prediction and drug screening in preclinical assay.Moreover,we shed light on the new research trends harnessing the power of AI for LO research in the context of multidisciplinary technologies.The aim of this paper is to motivate researchers to explore organ function throughout the human life cycle,narrow the gap between in vitro microphysiological models and the real human body,accurately predict human-related responses to external stimuli(cues and drugs),accelerate the preclinical-to-clinical transformation,and ultimately enhance the health and well-being of patients.

关 键 词：Artificial intelligence Human living organoids Organoid intelligence In vitro miniature organ models Multidisciplinary techniques Preclinical-to-clinical transformation 

分 类 号：TP18[自动化与计算机技术—控制理论与控制工程]