Dynamic compliance penis enlargement patch  

作　　者：Rui Zheng Wenwen Zhong Muyuan Chai Xuetao Shi 

机构地区：[1]National Engineering Research Centre for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou,510006,PR China [2]School of Materials Science and Engineering,South China University of Technology,Guangzhou,510640,PR China [3]Department of Urology,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,510655,PR China [4]Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine,The Tenth Affiliated Hospital,Southern Medical University,Dongguan,523000,PR China [5]Key Laboratory of Biomedical Engineering of Guangdong Province,South China University of Technology,Guangzhou,510006,PR China

出　　处：《Bioactive Materials》2024年第12期194-206,共13页生物活性材料（英文）

基　　金：the financial support from the National Key Research and Development Program of China(2021YFB3800800);the National Natural Science Foundation of China(U22A20157,32401141);the Guangdong Basic and Applied Basic Research Foundation(2022B1515130010,2023A1515110794,2024B1515040030);the Postdoctoral Fellowship Program of CPSF under Grant Number GZC20231080;the China Postdoctoral Science Foundation(2024M751311).

摘　　要：Men are particularly sensitive to penis size,especially those with a deformed or injured penis.This can lead to a strong desire for penis enlargement surgery.Given the ethical sensitivities of the penis,penile implants need to be developed with both efficacy and safety.In this study,a polyvinyl alcohol(PVA)patch for penile enlargement prepared via cyclic freeze‒thaw cycles and alkaline treatment.The PVA hydrogels treated with 5 M NaOH had the best mechanical properties and stability.A negative Poisson’s ratio structure is incorporated into the design of the enlargement patch,which allows it to conform well to the deformation of the penis.In rabbit models,the enlarged patches can effectively enlarge the penis without degradation or fibrosis while maintaining long-term stability in vivo.This innovation not only provides a safe option for patients in need of penile enlargement but also promises to make a broader contribution to the field of dynamic tissue repair.

关 键 词：Polyvinyl alcohol HYDROGEL Negative Poisson’s ratio Crystallization enhancement Penis enlargement 

分 类 号：R697.1[医药卫生—泌尿科学]