Emerging biomedical technologies for scarless wound healing  

作　　者：Xinyue Cao Xiangyi Wu Yuanyuan Zhang Xiaoyun Qian Weijian Sun Yuanjin Zhao 

机构地区：[1]Department of Otolaryngology Head and Neck Surgery,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China [2]Department of Gastrointestinal Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325035,China [3]Shenzhen Research Institute,Southeast University,Shenzhen,518071,China

出　　处：《Bioactive Materials》2024年第12期449-477,共29页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFB4700100);the National Natural Science Foundation of China(T2225003,52073060 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Science and Technology Program(JCYJ20210324133214038).

摘　　要：Complete wound healing without scar formation has attracted increasing attention,prompting the development of various strategies to address this challenge.In clinical settings,there is a growing preference for emerging biomedical technologies that effectively manage fibrosis following skin injury,as they provide high efficacy,cost-effectiveness,and minimal side effects compared to invasive and costly surgical techniques.This review gives an overview of the latest developments in advanced biomedical technologies for scarless wound management.We first introduce the wound healing process and key mechanisms involved in scar formation.Subsequently,we explore common strategies for wound treatment,including their fabrication methods,superior performance and the latest research developments in this field.We then shift our focus to emerging biomedical technologies for scarless wound healing,detailing the mechanism of action,unique properties,and advanced practical applications of various biomedical technology-based therapies,such as cell therapy,drug therapy,biomaterial therapy,and synergistic therapy.Finally,we critically assess the shortcomings and potential applications of these biomedical technologies and therapeutic methods in the realm of scar treatment.

关 键 词：Biomedical technologies Scarless wound healing Nonsurgical therapies Biomaterial Drug delivery 

分 类 号：R318[医药卫生—生物医学工程]