Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution  

作　　者：Lenka Drotarova Karel Slamecka Tomas Balint Michaela Remesova Radovan Hudak Jozef Zivcak Marek Schnitzer Ladislav Celko Edgar B.Montufar 

机构地区：[1]Central European Institute of Technology,Brno University of Technology,Purkynova 123,Brno,61200,Czech Republic [2]Faculty of Mechanical Engineering,Brno University of Technology,Technicka 2,Brno 61669,Czech Republic [3]Department of Biomedical Engineering and Measurement,Faculty of Mechanical Engineering,Technical University of Kosice,Letna 9,Kosice,04200,Slovakia

出　　处：《Bioactive Materials》2024年第12期519-530,共12页生物活性材料（英文）

基　　金：supported by the Ministry of Health of the Czech Republic(NW24-10-00195);the Brno University of Technology projects CEITEC VUT/FCH-J-23-8367 and CEITEC VUT-JL 24-8642;CzechNanoLab Research Infrastructure supported by Ministry of Education,Youth and Sports of the Czech Republic(LM2023051)providing access to some devices used for this study.

摘　　要：Biodegradable magnesium implants offer a solution for bone repair without the need for implant removal.However,concerns persist regarding peri-implant gas accumulation,which has limited their widespread clinical acceptance.Consequently,there is a need to minimise the mass of magnesium to reduce the total volume of gas generated around the implants.Incorporating porosity is a direct approach to reducing the mass of the implants,but it also decreases the strength and degradation resistance.This study demonstrates that the infiltration of a calcium phosphate cement into an additively manufactured WE43 Mg alloy scaffold with 75% porosity,followed by hydrothermal treatment,yields biodegradable magnesium/hydroxyapatite interpenetrating phase composites that generate an order of magnitude less hydrogen gas during degradation than WE43 scaffolds.The enhanced degradation resistance results from magnesium passivation,allowing osteoblast proliferation in indirect contact with composites.Additionally,the composites exhibit a compressive strength 1.8 times greater than that of the scaffolds,falling within the upper range of the compressive strength of cancellous bone.These results emphasise the potential of the new biodegradable interpenetrating phase composites for the fabrication of temporary osteosynthesis devices.Optimizing cement hardening and magnesium passivation during hydrothermal processing is crucial for achieving both high compressive strength and low degradation rate.

关 键 词：MAGNESIUM Biodegradable metal Calcium phosphate cement HYDROXYAPATITE Composite 

分 类 号：TG146.22[一般工业技术—材料科学与工程]