Highly plastic Zn-0.3Ca alloy for guided bone regeneration membrane:Breaking the trade-off between antibacterial ability and biocompatibility  

作　　者：Xiang-Min Li Zhang-Zhi Shi Ayisulu Tuoliken Wei Gou Chang-Heng Li Lu-Ning Wang 

机构地区：[1]Beijing Advanced Innovation Center for Materials Genome Engineering,State Key Laboratory for Advance Metals and Materials,School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing,100083,China [2]Institute of Materials Intelligent Technology,Liaoning Academy of Materials,Shenyang,110004,China

出　　处：《Bioactive Materials》2024年第12期550-572,共23页生物活性材料（英文）

基　　金：financially supported by Xiongan New Area Science and Technology Innovation Project(2022XACX0600);the National Natural Science Foundation of China(No.52231010 and No.52071028);Beijing Nova Program(2022 Beijing Nova Program Cross Cooperation Program No.20220484178).

摘　　要：A common problem for Zn alloys is the trade-off between antibacterial ability and biocompatibility.This paper proposes a strategy to solve this problem by increasing release ratio of Ca^(2+)ions,which is realized by significant refinement of CaZn13 particles through bottom circulating water-cooled casting(BCWC)and rolling.Compared with conventionally fabricated Zn-0.3Ca alloy,the BCWC-rolled alloy shows higher antibacterial abilities against E.coli and S.aureus,meanwhile much less toxicity to MC3T3-E1 cells.Additionally,plasticity,degradation uniformity,and ability to induce osteogenic differentiation in vitro of the alloy are improved.The elongation up to 49%,which is the highest among Zn alloys with Ca,and is achieved since the sizes of CaZn_(13) particles and Zn grains are small and close.As a result,the long-standing problem of low formability of Zn alloys containing Ca has also been solved due to the elimination of large CaZn_(13) particles.The BCWC-rolled alloy is a promising candidate of making GBR membrane.

关 键 词：Biodegradable Zn alloys Second phase refinement High plasticity Antibacterial ability BIOCOMPATIBILITY 

分 类 号：TG146[一般工业技术—材料科学与工程]