Biliary stents for active materials and surface modification:Recent advances and future perspectives  

作　　者：Yuechuan Li Kunshan Yuan Chengchen Deng Hui Tang Jinxuan Wang Xiaozhen Dai Bing Zhang Ziru Sun Guiying Ren Haijun Zhang Guixue Wang 

机构地区：[1]Key Laboratory for Biorheological Science and Technology of Ministry of Education,National Local Joint Engineering Laboratory for Vascular Implants,Bioengineering College of Chongqing University,Chongqing,400044,China [2]Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai,200092,China [3]National United Engineering Laboratory for Biomedical Material Modification,Dezhou,251100,China [4]School of Biosciences and Technology,Chengdu Medical College,Chengdu,610500,China [5]Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine(CVIHEM),Drum Tower Hospital,Nanjing University,Nanjing,China [6]College of materials science and engineering,Shandong University of Technology,Zibo,25500,Shandong,China

出　　处：《Bioactive Materials》2024年第12期587-612,共26页生物活性材料（英文）

基　　金：supported by grants from the Fundamental Research Funds for the Central Universities(No.2024CDJCGJ-016);National Natural Science Foundation of China(No.82270535);the Science and Technology Innovation Project of Jinfeng Laboratory,Chongqing,China(jfkyjf202203001);China Postdoctoral Science Foundation(2023MD734198).

摘　　要：Demand for biliary stents has expanded with the increasing incidence of biliary disease.The implantation of plastic or self-expandable metal stents can be an effective treatment for biliary strictures.However,these stents are nondegradable and prone to restenosis.Surgical removal or replacement of the nondegradable stents is necessary in cases of disease resolution or restenosis.To overcome these shortcomings,improvements were made to the materials and surfaces used for the stents.First,this paper reviews the advantages and limitations of nondegradable stents.Second,emphasis is placed on biodegradable polymer and biodegradable metal stents,along with functional coatings.This also encompasses tissue engineering&3D-printed stents were highlighted.Finally,the future perspectives of biliary stents,including pro-epithelialization coatings,multifunctional coated stents,biodegradable shape memory stents,and 4D bioprinting,were discussed.

关 键 词：Biliary stent BIODEGRADABLE Functional coatings Tissue engineering&3D-printed stent Shape memory 

分 类 号：R318[医药卫生—生物医学工程]