Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance  

作　　者：Saima Hameed Sumaira Sharif Muhammad Ovais Hai Xiong 

机构地区：[1]Institute for Advanced Study,Shenzhen University,Shenzhen,518060,PR China [2]School of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen,518060,PR China [3]Institute of Molecular Biology and Biotechnology,The University of Lahore,Lahore,Pakistan [4]BGI Genomics,BGI Shenzhen,Shenzhen,518083,Guangdong,PR China

出　　处：《Bioactive Materials》2024年第8期225-257,共33页生物活性材料（英文）

基　　金：supported by the Science and Technology Innovation Commission of Shenzhen,China(20231121191245001 and JCYJ20210324095607021 to HX);the Special Project of Key Fields of Universities in Guangdong Province,China(2021ZDZX2047 to HX).

摘　　要：The number of multi-drug-resistant bacteria has increased over the last few decades,which has caused a detrimental impact on public health worldwide.In resolving antibiotic resistance development among different bacterial communities,new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing the slow discovery of new functioning antibiotics.Advanced research studies have revealed the significant disinfection potential of two-dimensional nanomaterials(2D NMs)to be severed as effective antibacterial agents due to their unique physicochemical properties.This review covers the current research progress of 2D NMs-based antibacterial strategies based on an inclusive explanation of 2D NMs’impact as antibacterial agents,including a detailed introduction to each possible well-known antibacterial mechanism.The impact of the physicochemical properties of 2D NMs on their antibacterial activities has been deliberated while explaining the toxic effects of 2D NMs and discussing their biomedical significance,dysbiosis,and cellular nanotoxicity.Adding to the challenges,we also discussed the major issues regarding the current quality and availability of nanotoxicity data.However,smart advancements are required to fabricate biocompatible 2D antibacterial NMs and exploit their potential to combat bacterial resistance clinically.

关 键 词：2D nanomaterials Physicochemical properties Antibacterial mechanism Multi-drug-resistance Cellular nanotoxicity Nanotoxicity data availability 

分 类 号：TB383[一般工业技术—材料科学与工程]