Strategies of functionalized GelMA-based bioinks for bone regeneration:Recent advances and future perspectives  

作　　者：Yaru Zhu Xingge Yu Hao Liu Junjun Li Mazaher Gholipourmalekabadi Kaili Lin Changyong Yuan Penglai Wang 

机构地区：[1]School of Stomatology,Xuzhou Medical University,Affiliated Stomatological Hospital of Xuzhou Medical University,Xuzhou,China [2]Quanzhou Women’s and Children’s Hospital,Quanzhou,China [3]Department of Oral and Cranio-maxillofacial Science,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Research Unit of Oral and Maxillofacial Regenerative Medicine,Chinese Academy of Medical Sciences,Shanghai,China [4]Cellular and Molecular Research Center,Iran University of Medical Sciences,Department of Medical Biotechnology,Faculty of Allied Medicine,Tehran,Iran

出　　处：《Bioactive Materials》2024年第8期346-373,共28页生物活性材料（英文）

基　　金：The National Key R&D Program of China(2023YFC2414100);National Natural Science Foundation of China(32271379,82072396 and 81700954);Science and Technology Commission of Shanghai Municipality(21490711700);the Interdisciplinary Program of Shanghai Jiao Tong University(YG2021ZD12);Cross Disciplinary Research Fund of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(JYJC202219);Shanghai’s Top Priority Research Center(2022ZZ01017);CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-037)supported this work.

摘　　要：Gelatin methacryloyl(GelMA)hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties,which has been widely used in a variety of tissue engineering and tissue regeneration.However,pure GelMA is limited by the weak mechanical strength and the lack of continuous osteogenic induction environment,which is difficult to meet the needs of bone repair.Moreover,GelMA hydrogels are unable to respond to complex stimuli and therefore are unable to adapt to physiological and pathological microenvironments.This review focused on the functionalization strategies of GelMA hydrogel based bioinks for bone regeneration.The synthesis process of GelMA hydrogel was described in details,and various functional methods to meet the requirements of bone regeneration,including mechanical strength,porosity,vascularization,osteogenic differentiation,and immunoregulation for patient specific repair,etc.In addition,the response strategies of smart GelMA-based bioinks to external physical stimulation and internal pathological microenvironment stimulation,as well as the functionalization strategies of GelMA hydrogel to achieve both disease treatment and bone regeneration in the presence of various common diseases(such as inflammation,infection,tumor)are also briefly reviewed.Finally,we emphasized the current challenges and possible exploration directions of GelMA-based bioinks for bone regeneration.

关 键 词：GelMA FUNCTIONALIZATION Bone regeneration STIMULI-RESPONSIVE 3D bioprinting 

分 类 号：O63[理学—高分子化学]