Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair  

作　　者：Nailin Yang Xiaoyuan Yang Shuning Cheng Xiang Gao Shumin Sun Xuan Huang Jun Ge Zhihui Han Cheng Huang Yuanjie Wang Chong Cheng Liang Cheng 

机构地区：[1]Macao Institute of Materials Science and Engineering,Macao University of Science and Technology,Taipa,999078,Macao SAR,China [2]Institute of Functional Nano&Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou,215123,China [3]Department of Orthopedics,The Second Affiliated Hospital of Soochow University,Suzhou,215004,China [4]Department of Orthopedics,The First Affiliated Hospital of Soochow University,Suzhou,215006,China [5]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu,610065,China

出　　处：《Bioactive Materials》2024年第8期374-383,共10页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFB3804600,2021YFF0701800);the National Natural Science Foundation of China(U20A20254,52072253);the Science and Technology Development Fund,Macao SAR(0118/2023/RIA2);Collaborative Innovation Center of Suzhou Nano Science and Technology,Suzhou Key Laboratory of Nanotechnology and Biomedicine,the Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544);the 111 Project,Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,Medical Research Project of Jiangsu Province(ZD2022024);New Cornerstone Science Foundation through the XPLORER PRIZE,and Key Laboratory of Structural Deformities in Children of Suzhou(SZS2022018);N.Y.was supported by the Macao Young Scholars Program and the Jiangsu Funding Program for Excellent Postdoctoral Talent.

摘　　要：Implant-related osteomyelitis is a formidable hurdle in the clinical setting and is characterized by inflammation,infection,and consequential bone destruction.Therefore,effective reactive oxygen species(ROS)scavenging,bacterial killing,and subsequent bone tissue repair are urgently needed for the treatment of difficult-to-heal osteomyelitis.Herein,we utilized the eddy-thermal effect of magnesium(Mg)implants under an alternating magnetic field(AMF)for the controlled release of H_(2)gas and ions(OH^(-)and Mg^(2+))for the treatment of osteomyelitis.H_(2)released by Mg rods under AMFs effectively scavenged cytotoxic ROS,exhibiting anti-inflammatory effects and consequently disrupting the environment of bacterial infections.In addition,the OH-hindered the energy metabolism of bacteria by effectively neutralizing protons within the microenvironment.Moreover,H_(2)impaired the permeability of bacterial membranes and expedited the damage induced by OH-.This synergistic AMF-induced H_(2)and proton depletion treatment approach not only killed both gram-negative and gram-positive bacteria but also effectively treated bacterial infections(abscesses and osteomyelitis).Moreover,Mg^(2+)released from the Mg rods enhanced and accelerated the process of bone osteogenesis.Overall,our work cleverly exploited the eddy-thermal effect and chemical activity of Mg implants under AMFs,aiming to eliminate the inflammatory environment and combat bacterial infections by the simultaneous release of H_(2),OH^(-),and Mg^(2+),thereby facilitating tissue regeneration.This therapeutic strategy achieved multiple benefits in one,thus presenting a promising avenue for clinical application.

关 键 词：Magnesium implants Bacterial infection Alternating magnetic field Gas therapy Proton consumption ANTI-INFLAMMATORY 

分 类 号：R318[医药卫生—生物医学工程]