Thermo-sensitive Poloxamer based antibacterial anti-inflammatory and photothermal conductive multifunctional hydrogel as injectable,in situ curable and adjustable intraocular lens  

作　　者：Chen Qin Fan Fei Youfei Wei Yuemei Han Di Hu Quankui Lin 

机构地区：[1]National Engineering Research Center of Ophthalmology and Optometry,School of Biomedical Engineering,School of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China

出　　处：《Bioactive Materials》2024年第11期30-45,共16页生物活性材料（英文）

基　　金：Zhejiang Provincial Natural Science Foundation[LR23H180001];Key Scientific and Technological Innovation Projects in Wenzhou[ZY2021002].

摘　　要：Cataract patients look forwards to fewer postoperative complications and higher vision quality after surgery.However,the current intraocular lens(IOL)implanted after cataract surgery neither can adjust focal length in response to ciliary muscle contraction as natural lens nor have the ability to prevent postoperative complications.Herein,a thermosensitve Poloxamer based hybrid hydrogel with antibacterial anti-inflammatory and photothermal functional elements doping was designed and used as injectable,in situ curable,and adjustable IOL(FHTAB IOL).The FHTAB IOL was composed of thermosensitve triblock-polymer F127DA and a small amount of HAMA,combined with BP NS,TA,and Ag NPs.FHTAB IOL can be injected into the empty lens capsule after cataract surgery via an injectable thermos-gel under NIR illumination and then be rapidly cured to form a full-size IOL under short-time blue light irradiation.The designed injectable FHTAB IOL possesses high transparency and transmittance,with a refractive index similar to the natural lens and adjustable properties.It was stabilized as a refractive medium without any leakage in the eye.In addition,the TA and Ag NPs loaded in the FHTAB IOL displayed significant antibacterial and anti-inflammatory effects in vitro and vivo.This study presents a potentially effective new strategy for the development of multifunctional adjustable IOLs.

关 键 词：Adjustable IOL Injectable hydrogel ANTIBACTERIAL ANTI-INFLAMMATORY 

分 类 号：R318[医药卫生—生物医学工程]