Barnacle inspired strategy combined with solvent exchange for enhancing wet adhesion of hydrogels to promote seawater-immersed wound healing  

作　　者：Guiyuan Zhao Aijia Zhang Xiangyan Chen Guangli Xiang Tianze Jiang Xia Zhao 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education,Shandong Key Laboratory of Glycoscience and Glycotechnology,School of Medicine and Pharmacy,Ocean University of China,Qingdao,266003,China [2]Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology,Qingdao,266237,China

出　　处：《Bioactive Materials》2024年第11期46-60,共15页生物活性材料（英文）

基　　金：National Natural Science Foundation of China(U21A20297);Natural Science Foundation of Qingdao(202406).

摘　　要：Hydrogels are promising materials for wound protection,but in wet,or underwater environments,the hydration layer and swelling of hydrogels can seriously reduce adhesion and limit their application.In this study,inspired by the structural characteristics of strong barnacle wet adhesion and combined with solvent exchange,a robust wet adhesive hydrogel(CP-Gel)based on chitosan and 2-phenoxyethyl acrylate was obtained by breaking the hydration layer and resisting swelling.As a result,CP-Gel exhibited strong wet adhesion to various interfaces even underwater,adapted to joint movement and skin twisting,resisted sustained rushing water,and sealed damaged organs.More importantly,on-demand detachment and controllable adhesion were achieved by promoting swelling.In addition,CP-Gel with good biosafety significantly promotes seawater-immersed wound healing and is promising for use in water-contact wound care,organ sealing,and marine emergency rescue.

关 键 词：BARNACLE Solvent exchange HYDROGEL Wet adhesion Wound healing 

分 类 号：O63[理学—高分子化学]