Intrinsically bioactive multifunctional Poly(citrate-curcumin) for rapid lung injury and MRSA infection therapy  

作　　者：Tongtong Leng Long Zhang Junping Ma Xiaoyan Qu Bo Lei 

机构地区：[1]Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an,710054,China [2]Department of Respiratory and Critical Care Medicine,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710004,China

出　　处：《Bioactive Materials》2024年第11期158-173,共16页生物活性材料（英文）

基　　金：National Natural Science Foundation of China(grant No.52172288);Young Talent Support Plan of Xi'an Jiaotong University of China(grant No.QY6J003)。

摘　　要：Dysregulated inflammation after trauma or infection could result in the further disease and delayed tissue reconstruction.The conventional anti-inflammatory drug treatment suffers to the poor bioavailability and side effects.Herein,we developed an amphiphilic multifunctional poly(citrate-polyglycol-curcumin)(PCGC)nano oligomer with the robust anti-inflammatory activity for treating acute lung injury(ALI)and Methicillin-resistant staphylococcus aureus(MRSA)infected wound.PCGC demonstrated the sustained curcumin release,inherent photoluminescence,good cellular compatibility,hemocompatibility,robust antioxidant activity and enhanced cellular uptake.PCGC could efficiently scavenge nitrogen-based free radicals,oxygen-based free radicals,and intracellular oxygen species,enhance the endothelial cell migration and reduce the expression of pro-inflammatory factors through the NF-κB signal pathway.Combined the anti-inflammation and antioxidant properties,PCGC can shortened the inflammatory process.In animal model of ALI,PCGC was able to reduce the pulmonary edema,bronchial cell infiltration,and lung inflammation,while exhibiting rapid metabolic behavior in vivo.The MRSA-infection wound model showed that PCGC significantly reduced the expression of pro-inflammatory factors,promoted the angiogenesis and accelerated the wound healing.The transcriptome sequencing and molecular mechanism studies further demonstrated that PCGC could inhibit multiple inflammatory related pathways including TNFAIP3,IL-15RA,NF-κB.This work demonstrates that PCGC is efficient in resolving inflammation and promotes the prospect of application in inflammatory diseases as the drug-loaded therapeutic system.

关 键 词：Bioactive materials Bioactive polymers Citrate polymer ANTI-INFLAMMATORY Inflammatory diseases 

分 类 号：R563[医药卫生—呼吸系统]