A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis:Antibacterial,hemostasis,immune reprogramming,pro-osteo-/angiogenesis and recruitment  

作　　者：Shiyuan Yang Yan Zhu Chunxiao Ji Huimin Zhu An Lao Ran Zhao Yue Hu Yuning Zhou Jia Zhou Kaili Lin Yuanjin Xu 

机构地区：[1]Department of Oral Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai,China [3]Department of Oral and Cranio-maxillofacial Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]Department of Oral Mucosal Diseases,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《Bioactive Materials》2024年第11期239-256,共18页生物活性材料（英文）

基　　金：National Natural Science Foundation of China(82370921,82071082);Program of Shanghai Technology Research Leader(23XD1430800);Fund of Department of Oral and Maxillofacial Surgery(Department 2023-01).

摘　　要：Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues,resulting in tooth loss.Poor eradication of pathogenic microorganisms,persistent malignant inflammation and impaired osteo-/angiogenesis are currently the primary challenges to control disease progression and rebuild damaged alveolar bone.However,existing treatments for periodontitis fail to comprehensively address these issues.Herein,an injectable composite hydrogel(SFD/CS/ZIF-8@QCT)encapsulating quercetin-modified zeolitic imidazolate framework-8(ZIF-8@QCT)is developed.This hydrogel possesses thermo-sensitive and adhesive properties,which can provide excellent flowability and post-injection stability,resist oral fluid washout as well as achieve effective tissue adhesion.Inspirationally,it is observed that SFD/CS/ZIF-8@QCT exhibits a rapid localized hemostatic effect following implantation,and then by virtue of the sustained release of zinc ions and quercetin exerts excellent collective functions including antibacterial,immunomodulation,pro-osteo-/angiogenesis and pro-recruitment,ultimately facilitating excellent alveolar bone regeneration.Notably,our study also demonstrates that the inhibition of osteo-/angiogenesis of PDLSCs under the periodontitis is due to the strong inhibition of energy metabolism as well as the powerful activation of oxidative stress and autophagy,whereas the synergistic effects of quercetin and zinc ions released by SFD/CS/ZIF-8@QCT are effective in reversing these biological processes.Overall,our study presents innovative insights into the advancement of biomaterials to regenerate alveolar bone in periodontitis.

关 键 词：Hydrogel PERIODONTITIS Alveolar bone regeneration QUERCETIN ZIF-8 

分 类 号：R318[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]