Plant-inspired visible-light-driven bioenergetic hydrogels for chronic wound healing  

作　　者：Yuping Jiang Xiaomin Feng Xin Qiao Yufeng Li Xiaozhuang Li Jinguang Yang Lu Han 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao,266003,China [2]Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center,Qingdao,266237,China [3]Key Laboratory of Tobacco Pest Monitoring&Integrated Management,Tobacco Research Institute of Chinese Academy of Agricultural Sciences,Qingdao,266101,China

出　　处：《Bioactive Materials》2024年第11期523-536,共14页生物活性材料（英文）

基　　金：Fundamental Research Funds for Central Universities(202241010);Natural Science Fund for Excellent Young Scholars of Shandong Province(ZR202110120029);Major science and technology projects(110202201020(LS-04));Open Project of the Key Laboratory for Tobacco Disease and Pest Monitoring and Comprehensive Management in the Tobacco Industry(KLTPMIMT2022-11).

摘　　要：Chronic bioenergetic imbalances and inflammation caused by hyperglycemia are obstacles that delay diabetic wound healing.However,it is difficult to directly deliver energy and metabolites to regulate intracellular energy metabolism using biomaterials.Herein,we propose a light-driven bioenergetic and oxygen-releasing hydrogel(PTKM@HG)that integrates the thylakoid membrane-encapsulated polyphenol nanoparticles(PTKM NPs)to regulate the energy metabolism and inflammatory response in diabetic wounds.Upon red light irradiation,the PTKM NPs exhibited oxygen generation and H2O2 deletion capacity through a photosynthetic effect to restore hypoxia-induced mitochondrial dysfunction.Meanwhile,the PTKM NPs could produce exogenous ATP and NADPH to enhance mitochondrial function and facilitate cellular anabolism by regulating the leucine-activated mTOR signaling pathway.Furthermore,the PTKM NPs inherited antioxidative and anti-inflammatory ability from polyphenol.Finally,the red light irradiated PTKM@HG hydrogel augmented the survival and migration of cells keratinocytes,and then accelerated angiogenesis and re-epithelialization of diabetic wounds.In short,this study provides possibilities for effectively treating diseases by delivering key metabolites and energy based on such a light-driven bioenergetic hydrogel.

关 键 词：Polyphenol nanoparticles Photosynthetic thylakoid Inflammation regulation Diabetic wound repairing Hydrogel 

分 类 号：TQ427.26[化学工程]