Biomimetic multi-channel nerve conduits with micro/nanostructures for rapid nerve repair  

作　　者：Xinqing Wang Shuo Chen Xiaolei Chen Juan Wu Zhenhua Huang Jing Wang Fangping Chen Changsheng Liu 

机构地区：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237,PR China [2]Engineering Research Center for Biomedical Materials of Ministry of Education,East China University of Science and Technology,Shanghai,200237,PR China

出　　处：《Bioactive Materials》2024年第11期577-596,共20页生物活性材料（英文）

基　　金：National Natural Science Foundation of China(No.32171342;51772100);National Key Research and Development Program of China(2023YFC2413600)。

摘　　要：Peripheral nervous system(PNS)injuries often lead to significant sensory and motor impairments.Traditional artificial nerve conduits,lacking anisotropic structures,have been associated with prolonged repair time and failures in nerve regeneration.This study aimed to address these challenges by developing a novel approach for rapid repair of peripheral nerve injuries(PNI).A 3D oriented fibers scaffold featuring distinct radial(RFs)and longitudinal(LFs)fibers orientations was engineered using coaxial electrospinning and gas directional foaming techniques.This scaffold was then integrated with a shape memory conduit to form a directional multi-channel nerve conduit with micro/nanostructures.The results revealed that the grooved surface of the fibers significantly improved cellular directional guidance,effectively facilitating the migration of SCs from the periphery towards the center and from the base to the apex of the scaffold.In a rat model with a 10 mm nerve defect,the ND-PLATMC/LF ND-PCL scaffold significantly enhanced nerve regeneration and motor function recovery within 4 weeks.These results suggest the potential of this innovative scaffold for efficient repair of the nerve injuries.

关 键 词：INJURIES fibers directional 

分 类 号：TB383[一般工业技术—材料科学与工程]