New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity  

作　　者：WANG Mengru WANG Qi MA Yanzi ZEB Muhammad Aurang LI Xiaoli SHEN Feng XIAO Weilie 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Key Laboratory of Research and Development for Natural Products,State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,School of Pharmacy and School of Chemical Science and Technology,Yunnan Uni-versity,Kunming 650500,China [2]State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China [3]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China [4]Southwest United Graduate School,Kunming 650592,China

出　　处：《Chinese Journal of Natural Medicines》2024年第11期1003-1010,共8页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22477108,82260682);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);the Scientific Research Fund of Yunnan Provincial Department ofEducation(No.2023Y0235)。

摘　　要：Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-membered ring system,while compounds 3-5 are characterized by progressively truncated carbon skeletons,containing 18,17,and 16 carbons,respectively.In addition,four known compounds 6-9 were also identified.Their structures were elucidated using advanced spectroscopic tech-niques,including nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),ultra-violet(UV),infrared radiation(IR),optical rotatory dispersion(ORD),DP4+analysis and electronic circular dichroism(ECD),sup-ported by quantum chemical calculations.Compounds 1-9 were evaluated for their anti-MRSA activity.Among them,compound 6 demonstrated significant anti-MRSA activity,with a minimum inhibitory concentration(MIC)of 16 μg·mL^(-1).

关 键 词：Callicarpa integerrima Halimane diterpenes Clerodane diterpenes Structure elucidationanti-MRSA 

分 类 号：R917[医药卫生—药物分析学]