Highly oxidized sesquiterpenoids from Parasenecio rubescens and assessment of their cytotoxicity  

作　　者：JIN An DUAN Fangfang RUAN Hanli 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,China

出　　处：《Chinese Journal of Natural Medicines》2024年第11期1020-1029,共10页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22077041,81803847 and 31770380).

摘　　要：A phytochemical investigation of the whole plant of Parasenecio rubescens(S.Moore)Y.L.Chen yielded 14 previ-ously undescribed,highly oxidized bisabolane-type sesquiterpenoids,named pararunines L-Y,along with one known oplopane-type sesquiterpenoid.The structural elucidation of these compounds was accomplished through comprehensive spectroscopic analysis,in-cluding nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS)techniques.Motivated by traditional uses and previous studies on this genus,all isolated compounds were subjected to in vitro cytotoxicity assays against four human cancer cell lines(MCF-7,Hela,HCT116,and HT-29).Considering that the reported chemical constituents of nu-merous other species within this genus primarily consist of eremophilane-type sesquiterpenoids,our findings not only expand the struc-tural diversity of bisabolane-type sesquiterpenoids but also contribute valuable scientific evidence to the chemotaxonomy of this genus.

关 键 词：Parasenecio rubescens Asteraceae Bisabolane-type sesquiterpenoids Oplopane-type sesquiterpenoid Cytotoxic activity 

分 类 号：R917[医药卫生—药物分析学]