Talaketides A-G,linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp.SCSIO 41027  

作　　者：CHEN Chunmei WANG Xueni FANG Wenxuan LIANG Jiaqi CAI Jian YANG Dehua LUO Xiaowei GAO Chenghai YI Xiangxi LIU Yonghong ZHOU Xuefeng 

机构地区：[1]CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China [2]Guangxi Zhuang Yao Medicine Center of Engineering and Technology,Guangxi University of Chinese Medicine,Nanning 530200,China [3]Guangxi Key Laboratory of Marine Drugs,Institute of Marine Drugs,Guangxi University of Chinese Medicine,Nanning 530200,China [4]The National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2024年第11期1047-1056,共10页中国天然药物（英文版）

基　　金：supported by the Key-Area Research and Development Program of Guangdong Province(No.2023B1111050008);the National Natural Science Foundation of China(Nos.U23A20528,U20A20101);Guangdong Local Innovation Team Program(No.2019BT02Y262);the Postdoctoral Fellowship Program of CPSF(No.GZC20232777).

摘　　要：Seven novel linear polyketides,talaketides A-G(1-7),were isolated from the rice media cultures of the mangrove sed-iment-derived fungus Talaromyces sp.SCSIO 41027.Among these,talaketides A-E(1-5)represented unprecedented unsaturated lin-ear polyketides with an epoxy ring structure.The structures,including absolute configurations of these compounds,were elucidated through detailed analyses of nuclear magnetic resonance(NMR)and high-resolution mass spectrometry(HR-MS)data,as well as elec-tronic custom distributors(ECD)calculations.In the cytotoxicity screening against prostate cancer cell lines,talaketide E(5)demon-strated a dose-dependent inhibitory effect on prostate cancer PC-3 cell lines,with an IC50 value of 14.44 μmol·L-1.Moreover,com-pound 5 significantly inhibited the cloning formation of PC-3 cell lines and arrested the cell cycle in S-phase,ultimately inducing ap-optosis.These findings indicate that compound 5 may serve as a promising lead compound for the development of a potential treat-ment for prostate cancer.

关 键 词：Mangrove sediment-derived fungus Talaromyces sp.Linear polyketides Cytotoxicity Prostate cancer 

分 类 号：R917[医药卫生—药物分析学]