Multioxidized polyketides from an endophytic Penicillium sp.YUD17006 associated with Gastrodia elata  

作　　者：LI Hongtao YANG Ruining XIE Fei XIE Tianpeng TANG Linhuan ZHOU Hao DING Zhongtao 

机构地区：[1]Key Laboratory of Functional Molecules Analysis and Bio transformation of Universities in Yunnan Province,Yunnan Charac-teristic Plant Extraction Laboratory,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China [2]School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical Uni-versity,Kunming 650500,China [3]College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China [4]Medicinal Plants Research Institute,Yunnan Academy of Agricultural Sciences,Kunming 650200,China

出　　处：《Chinese Journal of Natural Medicines》2024年第11期1057-1064,共8页中国天然药物（英文版）

基　　金：supported by the Natural Science Foundation of China(No.22267001);the Program for Innovative Research Team of Yunnan Province(No.202105AE160006);the Science and Technology Project of Yunnan Province(Nos.202201AT070225,202301AU070217);Yunnan University“Double First-Class”Construction Joint Project(No.202201BF070001-014);Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University(No.202301AY070001-186);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan Minzu University(No.MZY2205);he Program Innovative Research Team in Science and Technology in Kunming Medical University(No.CXTD202202)。

摘　　要：Three novel,highly oxygenated polyketides,multioketides A-C(1-3),and three previously described multioxidized aromatic polyketides(4-6),were isolated from an endophytic Penicillium sp.YUD17006 associated with Gastrodia elata.Their chem-ical structures were elucidated using extensive spectroscopic data,electronic circular dichroism calculations,and single X-ray diffrac-tion analysis.All metabolites were characterized by a typical α,β-unsaturated ketone fragment and exhibited a high degree of oxidation.Multioketides A and B were identified as a pair of epimers featuring a rare dihydroisobenzofuranone core.Multioketide C possessed a novel 5/6/6/6 heterotetracyclic chemical architecture with unusual 1,4-dioxin functionalities.Plausible biosynthetic pathways for 1-6 were proposed.Additionally,compound 3 demonstrated weak inhibitory activities against both acetylcholinesterase and protein tyr-osine phosphatase 1B.

关 键 词：Penicillium sp.Multioxidized polyketides Secondary metabolite Anti-acetylcholinesterase activity PTP1B inhibit-ory activity 

分 类 号：R284.1[医药卫生—中药学]