Photoredox/Ti dual-catalyzed dehydroxylative ring-opening Giese reaction of cyclobutanone oximes  

作　　者：Huaigui Li Yan Li Weidong Yuan Anling Qu Kang Chen Yingguang Zhu 

机构地区：[1]Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry,College of Sciences,Nanjing Agricultural University,Nanjing 210095,China

出　　处：《Green Synthesis and Catalysis》2024年第3期159-164,共6页绿色合成与催化（英文）

基　　金：grateful for the financial support from the National Natural Science Foundation of China(Nos.22101135 and 21502096);the Natural Science Foundation of Jiangsu Province(No.BK20150652);the Fundamental Research Funds for the Central Universities(Nos.KYQN2022058,KJQN201629 and XUEKEN2022032);“333 High-Level Talent Project”of Jiangsu Province.

摘　　要：A dehydroxylative ring-opening Giese reaction of cyclobutanone oximes enabled by photoredox/Ti dual catalysis has been reported in this work.This protocol avoids the prefunctionalization of oximes and the use of stoichiometric triarylphosphine reagents.It also features mild conditions,broad substrate scope and good functional group tolerance.The gram-scale reaction,product derivatization,late-stage functionalization of complex pharmaceutical and natural product derivatives,and oligopeptide modification exhibit the potential application of this methodology in synthetic chemistry.

关 键 词：Photoredox/Ti dual catalysis Dehydroxylative ring-opening Giese reaction Cyclobutanone oximes γ-Cyanoalkyl radical Distally cyano-substituted amides 

分 类 号：O62[理学—有机化学]