Copper-catalyzed 2,3-dihydro-1,2,4-triazoles synthesis through[3+2]-cycloaddition of nitrile ylides with azodicarboxylates  

作　　者：Bao-Gui Cai Qian Li Jun Xuan 

机构地区：[1]Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials,College of Chemistry&Chemical Engineering,Anhui University,Hefei,Anhui 230601,China [2]Key Laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University),Ministry of Education,Hefei 230601,China

出　　处：《Green Synthesis and Catalysis》2024年第3期191-194,共4页绿色合成与催化（英文）

基　　金：the National Natural Science Foundation of China(Nos.21971001 and 21702001)for financial support.

摘　　要：A copper-catalyzed three-component reaction of diazo compounds,nitriles,and azodicarboxylates to construct 2,3-dihydro-1,2,4-triazoles is reported.Key to the success is the utilization of azodicarboxylates to trap the in-situ formed nitrile ylides from diazo compounds by[3+2]-cycloaddition.Both the acceptor-only and donor-acceptor diazo compounds are all tolerated to the strategy.The synthetic value of this protocol is illustrated by gram-scale synthesis and valuable transformation of the obtained 2,3-dihydro-1,2,4-triazoles.

关 键 词：CYCLOADDITION Nitrile ylides 1 2 4-Triazoles 

分 类 号：O62[理学—有机化学]