Synthesis of highly functional quinazolins via metal-free,visible-light-enabled radical cascade arylation/cyclization of fluorinated imidoyl isothiocyanates  

作　　者：Yan Liang Weigen Du Xiaoqiong Zeng Tiebo Xiao Yubo Jiang 

机构地区：[1]Faculty of Science,Kunming University of Science and Technology,727 South Jingming Road,Chenggong District,Kunming 650500,China

出　　处：《Green Synthesis and Catalysis》2024年第3期200-204,共5页绿色合成与催化（英文）

基　　金：grateful to the National Natural Science Foundation of China,China(No.22161024)for the financial support.

摘　　要：A metal-free,efficient and easy-to-hand protocol for the synthesis of 2-perfluoroalkylquinazolins has been achieved by Eosin B catalyzed radical cascade arylation/cyclization reaction of fluorinated imidoyl isothiocyanates with aryldiazonium Salts.A variety of highly functionalized quinozaline derivatives bearing pharmaceutically important thiol and fluoroalkyl groups were efficiently assembled with broad substrate scope and good functional group tolerance.A series of mechanism experiments indicate that this reaction undergoes a radical cascade arylation/cyclization pathway.

关 键 词：METAL-FREE VISIBLE-LIGHT Radical cascade ISOTHIOCYANATES 2-Perfluoroalkyl quinazolins 

分 类 号：O62[理学—有机化学]