Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community  

作　　者：Shuiling He Ruipeng Yang Jiangying Shi Ning An Shuhua Shan Zhuoyu Li Xiushan Dong 

机构地区：[1]Institute of Biotechnology,Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education,Shanxi University,Taiyuan 030006,China [2]General Surgery Department,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Third Hospitalof Shanxi Medical University,Taiyuan 030032,China

出　　处：《Food Science and Human Wellness》2024年第6期3339-3350,共12页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(U23A20526,32072220,32270420);Shanxi Province 136 Revitalization Medical Project Construction Funds(general surgery department),Science Foundation(202103021224011).

摘　　要：Inflammatory bowel disease(IBD)is a chronic relapsing-remitting systemic disease of the gastrointestinal tract,characterized by an inflammatory process.Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD.Our previous findings indicated that polyphenol of the inner shell(BPIS)from foxtail millet bran could restore the gut microbiome and inhibit the progress of colorectal cancer(CRC).In the present study,we studied the anti-inflammatory potential of BPIS in the dextran sodium sulfate(DSS)-induced mouse colitis model.Data suggested that BPIS alleviated experimental colitis by restoring body weight,colonic length and protecting the epithelial architecture from damage by DSS.Moreover,we found that BPIS strengthened the gut barrier function and inhibited the activation of Wnt1/β-catenin pathway.Gene sequence analysis indicated that BPIS remodeled the overall structure of the gut mycobiota from colitis mice toward that of the normal counterparts,including 1 phylum and 9 genera.Interestingly,BPIS significantly increased the abundance of Aspergillus ruber.It further verified that BPIS significantly promoted the growth of A.ruber in vitro.Collectively,BPIS has great potential to develop into an effective against IBD drug.

关 键 词：Foxtail millet bran Inflammatory bowel disease Gut barrier Wnt1/β-catenin Fungal community Aspergillus ruber 

分 类 号：TQ460.1[化学工程—制药化工] TS210.9[轻工技术与工程—粮食、油脂及植物蛋白工程] R574.62[轻工技术与工程—食品科学与工程]